G
George W. Nelson
Researcher at Leidos
Publications - 84
Citations - 14306
George W. Nelson is an academic researcher from Leidos. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 44, co-authored 82 publications receiving 13204 citations. Previous affiliations of George W. Nelson include Science Applications International Corporation & National Institutes of Health.
Papers
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Journal ArticleDOI
African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans
Doron M. Behar,Saharon Rosset,Shay Tzur,Sara Selig,Sara Selig,Guennady Yudkovsky,Sivan Bercovici,Jeffrey B. Kopp,Cheryl A. Winkler,George W. Nelson,Walter G. Wasser,Karl Skorecki,Karl Skorecki +12 more
TL;DR: Findings strengthen the contention that a sequence variant of MYH9, common in populations with varying degrees of African ancestry admixture, and in strong linkage disequilibrium with the associated SNPs and haplotypes reported herein, strongly predisposes to non-diabetic ESKD.
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Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans
Barry I. Freedman,Carl D. Langefeld,Lingyi Lu,Jasmin Divers,Mary E. Comeau,Jeffrey B. Kopp,Cheryl A. Winkler,George W. Nelson,Randall C. Johnson,Randall C. Johnson,Nicholette D. Palmer,Pamela J. Hicks,Meredith A. Bostrom,Jessica N. Cooke,Caitrin W. McDonough,Donald W. Bowden +15 more
TL;DR: A role for FRMD3 in AA T2DN susceptibility and accounting for c22 nephropathy risk variants can assist in detecting DN susceptibility genes are revealed.
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Polygenic and multifactorial disease gene association in man: Lessons from AIDS
TL;DR: The integration of genetic associations, well-described clinical cohorts, extensive basic research on AIDS pathogenesis, and functional interpretation of gene connections to disease offers a formula for detecting such genes in complex human genetic phenotypes.
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Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.
Joshua T. Herbeck,Geoffrey S. Gottlieb,Cheryl A. Winkler,George W. Nelson,Ping An,Ping An,Brandon S. Maust,Kim G. Wong,Jennifer L. Troyer,James J. Goedert,Bailey Kessing,Roger Detels,Steven M. Wolinsky,Jeremy J. Martinson,Susan Buchbinder,Gregory D. Kirk,Lisa P. Jacobson,Joseph B. Margolick,Richard A. Kaslow,Stephen J. O'Brien,James I. Mullins +20 more
TL;DR: This study identified and replicated a locus upstream of PROX1 that is associated with delayed progression to clinical AIDS, a negative regulator of interferon-gamma expression in T cells and also mitigates the advancement of vascular neoplasms, such as Kaposi sarcoma, a common AIDS-defining malignancy.
Journal ArticleDOI
Influence of CCR5 promoter haplotypes on AIDS progression in African-Americans.
Ping An,Maureen P. Martin,George W. Nelson,Mary Carrington,Michael W. Smith,Kui Gong,David Vlahov,Stephen J. O'Brien,Cheryl A. Winkler +8 more
TL;DR: The composite CCR5P1 haplotype is shown to be associated with rapid progression to AIDS endpoints in both African–American and Caucasian cohorts, but the effect is recessive in Caucasians and dominant in African–Americans.