G
George W. Nelson
Researcher at Leidos
Publications - 84
Citations - 14306
George W. Nelson is an academic researcher from Leidos. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 44, co-authored 82 publications receiving 13204 citations. Previous affiliations of George W. Nelson include Science Applications International Corporation & National Institutes of Health.
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Journal ArticleDOI
Polymorphisms in the Nonmuscle Myosin Heavy Chain 9 Gene (MYH9) Are Associated with Albuminuria in Hypertensive African Americans: The HyperGEN Study
Barry I. Freedman,Jeffrey B. Kopp,Cheryl A. Winkler,George W. Nelson,D. C. Rao,John H. Eckfeldt,Mark Leppert,Pamela J. Hicks,Jasmin Divers,Carl D. Langefeld,Steven C. Hunt +10 more
TL;DR: MYH9 risk variants appear to be associated with primary FSGS with secondary hypertension, although nephrosclerosis may develop in response to hypertension in subjects homozygous for the MYH9 E1 risk haplotype.
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Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
George W. Nelson,Barry I. Freedman,Donald W. Bowden,Carl D. Langefeld,Ping An,Pamela J. Hicks,Meredith A. Bostrom,Randall C. Johnson,Jeffrey B. Kopp,Cheryl A. Winkler +9 more
TL;DR: Neither the highly associated SNPs nor the results of resequencing MYH9 in 40 HIVAN or FSGS cases and controls revealed non-synonymous changes that could account for the disease associations.
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Considering genetic profiles in functional studies of immune responsiveness to HIV-1.
TL;DR: Here, an approach is proposed for assessing overall genetic risk on an individual basis and it is suggested that this information be considered when selecting comparison groups in studies of immune responses to HIV and/or in the interpretation of data derived from such studies.
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Genome-Wide Association Study Implicates PARD3B-Based AIDS Restriction
Jennifer L. Troyer,George W. Nelson,James A. Lautenberger,Leslie W. Chinn,Carl E. Mcintosh,Randall C. Johnson,Efe Sezgin,Bailey Kessing,Michael Malasky,Sher L. Hendrickson,Guan Li,Joan Pontius,Minzhong Tang,Ping An,Cheryl A. Winkler,Sophie Limou,Sigrid Le Clerc,Olivier Delaneau,Jean Francxois Zagury,Hanneke Schuitemaker,Daniëlle van Manen,Jay H. Bream,Edward D. Gomperts,Susan Buchbinder,James J. Goedert,Gregory D. Kirk,Stephen J. O'Brien +26 more
TL;DR: Observations suggest a potential unsuspected pathway of host genetic influence on the dynamics of AIDS progression, as observed for SNPs in the gene PARD3B.
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Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+-T-Cell Responses for Groups of HIV-1-Infected Individuals with Different HLA-B*35 Genotypes
Xia Jin,Xiaojiang Gao,Murugappan Ramanathan,Geoffrey R. Deschenes,George W. Nelson,Stephen J. O'Brien,James J. Goedert,David D. Ho,Thomas R. O'Brien,Mary Carrington +9 more
TL;DR: The data are consistent with the hypothesis that higher levels of virus-specific CTL contribute to protection against HIV disease progression in infected individuals with B-35-PY, but not in those with B*35-px.