G
George W. Nelson
Researcher at Leidos
Publications - 84
Citations - 14306
George W. Nelson is an academic researcher from Leidos. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 44, co-authored 82 publications receiving 13204 citations. Previous affiliations of George W. Nelson include Science Applications International Corporation & National Institutes of Health.
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Journal ArticleDOI
Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: Study design, methods and feasibility
Xiu Chan Guo,Kevin Scott,Yan Liu,Michael Dean,Victor A. David,George W. Nelson,Randall C. Johnson,Holli H. Dilks,James A. Lautenberger,Bailey Kessing,Janice S. Martenson,Li Guan,Shan Sun,Hong Deng,Yuming Zheng,Jian Liao,Yi Zeng,Stephen J. O'Brien,Cheryl A. Winkler +18 more
TL;DR: A two-phase, population-based, case-control study of Han Chinese from Guangxi province, where the NPC incidence rate rises to a high of 25-50 per 100,000 individuals, and the Phase II study population has tripled patient enrolment and has included environmental covariates, offering the potential to validate the onset of NPC.
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Induction of DNMT3B by PGE2 and IL6 at distant metastatic sites promotes epigenetic modification and breast cancer colonization
Jae Young So,Nicolas Skrypek,Howard H. Yang,Anand S. Merchant,George W. Nelson,Wei Dong Chen,Hiroki Ishii,Jennifer M. Chen,Gangqing Hu,Bhagelu R. Achyut,Esther Yoon,Liying Han,Chuanshu Huang,Margaret C. Cam,Keji Zhao,Maxwell P. Lee,Li Yang +16 more
TL;DR: It is reported that DNA methyltransferase 3B (DNMT3B) is induced at distant metastatic sites and mediates epigenetic reprogramming of metastatic tumor cells and caution against the “Achilles heel” in cancer therapies based on primary tumor characterization.
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Sequencing rare and common APOL1 coding variants to determine kidney disease risk
Sophie Limou,George W. Nelson,Laurence Lecordier,Ping An,Colm O'hUigin,Victor A. David,Elizabeth A. Binns-Roemer,Wilfried Guiblet,Taras K. Oleksyk,Etienne Pays,Jeffrey B. Kopp,Cheryl A. Winkler +11 more
TL;DR: A third of African Americans with sporadic focal segmental glomerulosclerosis (FSGS) or HIV-associated nephropathy (HIVAN) do not carry APOL1 renal risk genotypes as mentioned in this paper.
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MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
TL;DR: No role has been established for genetic testing as part of personalized medicine, but testing should be considered in clinical studies of glomerular diseases among populations of African descent.
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Using Mutual Information to Measure the Impact of Multiple Genetic Factors on Aids
TL;DR: It is shown that 13 genetic factors can cumulatively explain 9% of slow progression to AIDS, an effect comparable to the effect of smoking on lung cancer.