G
Gerald L. Kennedy
Researcher at DuPont
Publications - 145
Citations - 4604
Gerald L. Kennedy is an academic researcher from DuPont. The author has contributed to research in topics: Toxicity & Developmental toxicity. The author has an hindex of 32, co-authored 145 publications receiving 4278 citations.
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Journal ArticleDOI
The toxicology of perfluorooctanoate.
Gerald L. Kennedy,John L. Butenhoff,Geary W. Olsen,John C. O'Connor,Andrew M. Seacat,Roger Perkins,Lisa B. Biegel,Sandra R. Murphy,David G. Farrar +8 more
TL;DR: The hepatocellular tumors observed in rats are likely to have been the result of the activation of the peroxisome proliferator activated receptor α (PPARα), and the proposed mechanism for Leydig-cell tumor formation is of questionable relevance to humans.
Journal ArticleDOI
Perfluoroalkyl Acids and Related Chemistries—Toxicokinetics and Modes of Action
Melvin E. Andersen,John L. Butenhoff,Shu Ching Chang,David G. Farrar,Gerald L. Kennedy,Christopher Lau,Geary W. Olsen,Jennifer Seed,Kendall B. Wallace +8 more
TL;DR: The toxicokinetic profiles of various PFAAs among animal models and humans, and the biological processes that are responsible for these observations are addressed, to examine the possible modes of action that determine the PFAA toxicities observed in animal models, and their relevance to human health risks.
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Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.
John L. Butenhoff,Giovanni Costa,Cliff Elcombe,David G. Farrar,Kristin Hansen,Hiroyuki Iwai,Reinhard Jung,Gerald L. Kennedy,Paul H. Lieder,Geary W. Olsen,Peter J. Thomford +10 more
TL;DR: There were no APFO-related macroscopic or microscopic changes, changes in clinical chemistry, hormones, or urinalysis, or hematological effects, and effects that have been associated with the development of pancreatic and testicular toxicity in rats were not observed in this study.
Journal ArticleDOI
The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat
TL;DR: The potential reproductive toxicity of APFO across two generations of offspring was studied using current EPA OPPTS 870.3800 guidelines and Reproductive endpoints including mating, fertility, and natural delivery were not affected in either generation.
Journal ArticleDOI
Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO).
Scott E. Loveless,Carol Finlay,Nancy E. Everds,Steven R. Frame,Peter J. Gillies,John C. O'Connor,Charles R. Powley,Gerald L. Kennedy +7 more
TL;DR: In both rats and mice, the overall responses to the linear/branched and the linear forms of PFOA were similar, but the branched form appears to be less potent.