G
Geraldine S. Pinkus
Researcher at Brigham and Women's Hospital
Publications - 286
Citations - 29136
Geraldine S. Pinkus is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Lymphoma & Immunoperoxidase. The author has an hindex of 84, co-authored 278 publications receiving 27112 citations. Previous affiliations of Geraldine S. Pinkus include University of Texas MD Anderson Cancer Center & Montreal General Hospital.
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Immunohistochemical analysis of langerin in langerhans cell histiocytosis and pulmonary inflammatory and infectious diseases.
TL;DR: Examination of expression patterns of S100, CD1a, and langerin in LCH and other interstitial, inflammatory, and infectious processes in cases retrieved from the files at Brigham and Women's Hospital Department of Pathology found Langerin andCD1a serve as specific diagnostic markers in distinguishing LCH from other interinterstitial and inflammatory processes.
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Extramammary Paget's disease of the perianal and perineal regions. Evidence of apocrine derivation.
TL;DR: The presence of gross cystic disease fluid protein--a new marker of apocrine epithelia--in Paget's cells provides additional insight into the histopathogenesis of this condition.
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CD4+/CD56+ hematodermic neoplasm ("blastic natural killer cell lymphoma"): neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon.
TL;DR: In all cases, neoplastic cells were reactive for CD123, BDCA-2, and MxA protein, providing strong evidence for an immature plasmacytoid DC derivation for this rare neoplasm.
Journal Article
Myeloperoxidase: a specific marker for myeloid cells in paraffin sections.
TL;DR: In normal tissues and in a variety of myeloproliferative disorders, myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibited strong cytoplasmic reactivity for myeloperoxidase.
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Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease
Bjoern Chapuy,Hongwei Cheng,Akira Watahiki,Matthew D. Ducar,Yuxiang Tan,Linfeng Chen,Margaretha G.M. Roemer,Jing Ouyang,Amanda L. Christie,Liye Zhang,Daniel Gusenleitner,Ryan Abo,Pedro Farinha,Frederike von Bonin,Aaron R. Thorner,Heather Sun,Randy D. Gascoyne,Geraldine S. Pinkus,Paul Van Hummelen,Gerald Wulf,Jon C. Aster,David M. Weinstock,Stefano Monti,Scott J. Rodig,Yuzhuo Wang,Margaret A. Shipp +25 more
TL;DR: A panel of large B-cell lymphoma (LBCL) patient-derived xenograft (PDX) models is generated, including 8 that reflect the immunophenotypes, transcriptional, genetic, and functional heterogeneity of primary DLBCL and 1 that is a plasmablastic lymphoma.