Gernot Marx

TL;DR: Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategies have failed to detect a robust benefit on mortality.

TL;DR: It is shown that administration of an established colloid 200/0.5 hydroxyethyl starch (HES) stabilized plasma volume in a porcine septic shock model with a new HES with a low molecular weight and lower molar substitution (0.42) attenuated capillary leakage significantly more effectively than HES 200/ 0.5.

TL;DR: Three newly developed synthetic anti-lipopolysaccharide peptides with a broader range of efficacy to suppress cytokine release in plasma and CD14 mRNA expression in organ tissue in a murine, polymicrobial sepsis model are compared.

TL;DR: Evidence is obtained that sCD74 inhibits MIF‐mediated survival pathway through the C‐X‐C chemokine receptor 4/AKT axis, enabling the induction of CD74‐dependent necroptotic processes in cardiac myofibroblasts, suggesting these proteins may be a promising target to modulate cardiac remodeling and disease progression in heart failure.

TL;DR: Serum levels of suPAR and proENK, but not of creatinine, were significantly higher before surgery in patients with subsequent AKI, indicating that suPAR may be a predictive biomarker for AKI in the context of cardiac surgery, even in patients without underlying CKD.