Gianluca Varetti

TL;DR: An engineered "bonsai" Ndc80 complex containing a shortened rod domain but retaining the globular domains required for kinetochore localization and microtubule binding is crystallized, revealing a microtubules-binding interface containing a pair of tightly interacting calponin-homology (CH) domains with a previously unknown arrangement.

TL;DR: A homeostatic network in which checkpoint-sustaining and -repressing forces oppose each other during mitotic arrest is revealed and ways for enhancing the sensitivity of cancer cells to antitubulin chemotherapeutics are suggested.

TL;DR: It is concluded that Rpl11-deficient mice recapitulate DBA disorder, including cancer predisposition, and fibroblasts and hematopoietic tissues from heterozygous RPL11 mice present higher basal cMYC levels.

TL;DR: The SAC as a synchronization device shows how the stability of cyclin B and securin is tuned on the ‘Wait!’ signal, these proteins are stabilized for the time required to achieve metaphase.

TL;DR: This work reviews recent progress in identifying how aneuploidy leads to genomic and chromosomal instability, how cells can adapt to the deleterious effects of aneuPLoidy, and howAneuploids contributes to tumorigenesis in different genetic contexts.