C
Calliope A. Dendrou
Researcher at University of Oxford
Publications - 42
Citations - 4144
Calliope A. Dendrou is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 31 publications receiving 3071 citations. Previous affiliations of Calliope A. Dendrou include Wellcome Trust Centre for Human Genetics & University of Cambridge.
Papers
More filters
Journal ArticleDOI
Immunopathology of multiple sclerosis
TL;DR: The current understanding of multiple sclerosis immunopathology is discussed, long-standing hypotheses regarding the role of the immune system in the disease are evaluated, and key questions that are still unanswered are delineated.
Journal ArticleDOI
HLA variation and disease
TL;DR: The scope for personalized antigen-specific disease prevention is evaluated, whereby harnessing HLA–ligand interactions for clinical benefit is becoming a realistic prospect.
Journal ArticleDOI
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
Adam Patrick Gregory,Calliope A. Dendrou,Kathrine E. Attfield,Aiden Haghikia,Aiden Haghikia,Dionysia K. Xifara,Falk Butter,Gereon Poschmann,Gurman Kaur,Lydia Lambert,Oliver A. Leach,Simone Prömel,Divya Punwani,James H. Felce,Simon J. Davis,Ralf Gold,Finn Cilius Nielsen,Richard M. Siegel,Matthias Mann,John I. Bell,Gil McVean,Lars Fugger,Lars Fugger +22 more
TL;DR: This study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation.
Journal ArticleDOI
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders
Jenny C. Taylor,Jenny C. Taylor,Hilary C. Martin,Stefano Lise,John Broxholme,Jean-Baptiste Cazier,Andrew J. Rimmer,Alexander Kanapin,Gerton Lunter,Simon Fiddy,Chris Allan,A. Radu Aricescu,Moustafa Attar,Christian Babbs,Jennifer Becq,David Beeson,Celeste Bento,P Bignell,Edward Blair,Veronica J. Buckle,Katherine R. Bull,Katherine R. Bull,Ondrej Cais,Holger Cario,Helen Chapel,Richard R. Copley,Richard R. Copley,Richard J. Cornall,Jude Craft,Jude Craft,Karin Dahan,Emma E. Davenport,Calliope A. Dendrou,Olivier Devuyst,Aimee L. Fenwick,Jonathan Flint,Lars Fugger,Rodney D. Gilbert,Anne Goriely,Angie Green,Ingo H. Greger,Russell J. Grocock,Anja V. Gruszczyk,Robert W. Hastings,Edouard Hatton,Doug Higgs,Adrian V. S. Hill,Adrian V. S. Hill,Christopher Holmes,Christopher Holmes,Malcolm F. Howard,Malcolm F. Howard,Linda Hughes,Peter Humburg,David W. Johnson,Fredrik Karpe,Zoya Kingsbury,Usha Kini,Julian C. Knight,Jon P. Krohn,Sarah Lamble,Craig B. Langman,Lorne Lonie,Joshua Luck,Davis J. McCarthy,Simon J. McGowan,Mary Frances McMullin,Kerry A. Miller,Lisa Murray,Andrea H. Németh,M. Andrew Nesbit,David J. Nutt,Elizabeth Ormondroyd,Annette Bang Oturai,Alistair T. Pagnamenta,Alistair T. Pagnamenta,Smita Y. Patel,Melanie J. Percy,Nayia Petousi,Paolo Piazza,Sian E. Piret,Guadalupe Polanco-Echeverry,Niko Popitsch,Niko Popitsch,Fiona Powrie,Christopher W. Pugh,Lynn Quek,Peter A. Robbins,Kathryn J. H. Robson,Alexandra Russo,Natasha Sahgal,Pauline A. van Schouwenburg,Anna Schuh,Anna Schuh,Earl D. Silverman,Alison Simmons,Per Soelberg Sørensen,Elizabeth Sweeney,John Taylor,John Taylor,Rajesh V. Thakker,Ian Tomlinson,Ian Tomlinson,Amy Trebes,Stephen R.F. Twigg,Holm H. Uhlig,Paresh Vyas,Timothy J. Vyse,Steven A. Wall,Hugh Watkins,Michael P. Whyte,Lorna Witty,Ben Wright,Christopher Yau,David Buck,Sean Humphray,Peter J. Ratcliffe,John I. Bell,Andrew O.M. Wilkie,David Bentley,Peter Donnelly,Peter Donnelly,Gilean McVean +122 more
TL;DR: It is found that jointly calling variants across samples, filtering against both local and external databases, deploying multiple annotation tools and using familial transmission above biological plausibility contributed to accuracy.
Journal ArticleDOI
Class II HLA interactions modulate genetic risk for multiple sclerosis
Loukas Moutsianas,Luke Jostins,Ashley Beecham,Alexander T. Dilthey,Dionysia Kiara Xifara,Maria Ban,Tejas Shah,Nikolaos A. Patsopoulos,Lars Alfredsson,Carl A. Anderson,Kathrine E. Attfield,Sergio E. Baranzini,Jeffrey C. Barrett,Binder Tmc.,David R. Booth,Dorothea Buck,Elisabeth Gulowsen Celius,Chris Cotsapas,Sandra D'Alfonso,Calliope A. Dendrou,Peter Donnelly,Bénédicte Dubois,Bertrand Fontaine,Lars Fugger,An Goris,Gourraud P-A.,Christiane Graetz,B. Hemmer,Jan Hillert,Ingrid Kockum,Stephen Leslie,Christina M. Lill,F. Martinelli-Boneschi,Jorge R. Oksenberg,Tomas Olsson,Annette Bang Oturai,Janna Saarela,Helle Bach Søndergaard,Anne Spurkland,Bruce V. Taylor,Juliane Winkelmann,Frauke Zipp,Jonathan L. Haines,Margaret A. Pericak-Vance,Spencer Cca.,Graeme J. Stewart,David A. Hafler,Adrian J. Ivinson,Hanne F. Harbo,Stephen L. Hauser,P. L. De Jager,A Compston,Jacob L. McCauley,Stephen Sawcer,Gil McVean +54 more
TL;DR: A high-resolution map of HLA genetic risk is built and evidence for interactions involving classical HLA alleles and non-HLA risk-associated variants is found, estimating a minimal effect of polygenic epistasis in modulating major risk alleles.