G
Gitte Neubauer
Researcher at European Bioinformatics Institute
Publications - 48
Citations - 14123
Gitte Neubauer is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Phosphorylation & Spliceosome. The author has an hindex of 30, co-authored 48 publications receiving 13629 citations.
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Journal ArticleDOI
Functional organization of the yeast proteome by systematic analysis of protein complexes
Anne-Claude Gavin,Markus Bösche,Roland Krause,Paola Grandi,Martina Marzioch,Andreas Bauer,Jörg Schultz,Jens Rick,Anne-Marie Michon,Cristina-Maria Cruciat,Marita Remor,Christian Höfert,Malgorzata Schelder,Miro Brajenovic,Heinz Ruffner,Alejandro Merino,Karin Klein,Manuela Hudak,David Dickson,Tatjana Rudi,Volker Gnau,Angela Bauch,Sonja Bastuck,Bettina Huhse,Christina Leutwein,Marie-Anne Heurtier,Richard R. Copley,Angela Edelmann,Erich Querfurth,Vladimir Rybin,Gerard Drewes,Manfred Raida,Tewis Bouwmeester,Peer Bork,Bertrand Séraphin,Bernhard Kuster,Gitte Neubauer,Giulio Superti-Furga +37 more
TL;DR: The analysis provides an outline of the eukaryotic proteome as a network of protein complexes at a level of organization beyond binary interactions, which contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery.
Journal ArticleDOI
Proteome survey reveals modularity of the yeast cell machinery
Anne-Claude Gavin,Patrick Aloy,Paola Grandi,Roland Krause,Markus Boesche,Martina Marzioch,Christina Rau,Lars Juhl Jensen,Sonja Bastuck,Birgit Dümpelfeld,Angela Edelmann,Marie-Anne Heurtier,Verena Hoffman,Christian Hoefert,Karin Klein,Manuela Hudak,Anne-Marie Michon,Malgorzata Schelder,Markus Schirle,Marita Remor,Tatjana Rudi,Sean D. Hooper,Andreas Bauer,Tewis Bouwmeester,Georg Casari,Gerard Drewes,Gitte Neubauer,Jens Rick,Bernhard Kuster,Peer Bork,Robert B. Russell,Giulio Superti-Furga +31 more
TL;DR: This study reports the first genome-wide screen for complexes in an organism, budding yeast, using affinity purification and mass spectrometry and provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling.
Journal ArticleDOI
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Marcus Bantscheff,Dirk Eberhard,Yann Abraham,Sonja Bastuck,Markus Boesche,Scott Hobson,Toby Mathieson,Jessica Perrin,Manfred Raida,Christina Rau,Valerie Reader,Gavain Sweetman,Andreas Bauer,Tewis Bouwmeester,Carsten Hopf,Ulrich Kruse,Gitte Neubauer,Nigel Ramsden,Jens Rick,Bernhard Kuster,Gerard Drewes +20 more
TL;DR: Quantitative profiling of the drugs Imatinib, dasatinib and bosutinib in K562 cells confirms known targets including ABL and SRC family kinases and identifies the receptor tyrosine kinase DDR1 and the oxidoreductase NQO2 as novel targets of imatinib.
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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Tewis Bouwmeester,Angela Bauch,Heinz Ruffner,Pierre-Olivier Angrand,Giovanna Bergamini,Karen Croughton,Cristina Cruciat,Dirk Eberhard,Julien Gagneur,Sonja Ghidelli,Carsten Hopf,Bettina Huhse,Raffaella Mangano,Anne-Marie Michon,Markus Schirle,Judith Schlegl,Markus Schwab,Martin Stein,Andreas Bauer,Georg Casari,Gerard Drewes,Anne-Claude Gavin,David B. Jackson,Gerard Joberty,Gitte Neubauer,Jens Rick,Bernhard Kuster,Giulio Superti-Furga +27 more
TL;DR: The mapping of a protein interaction network around 32 known and candidate TNF-α/NF-κB pathway components is reported by using an integrated approach comprising tandem affinity purification, liquid-chromatography tandem mass spectrometry, network analysis and directed functional perturbation studies using RNA interference.
Journal ArticleDOI
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
Marcus Bantscheff,Carsten Hopf,Mikhail M. Savitski,Antje Dittmann,Paola Grandi,Anne-Marie Michon,Judith Schlegl,Yann Abraham,Isabelle Becher,Giovanna Bergamini,Markus Boesche,Manja Delling,Birgit Dümpelfeld,Dirk Eberhard,Carola Huthmacher,Toby Mathieson,Daniel Poeckel,Valerie Reader,Katja Strunk,Gavain Sweetman,Ulrich Kruse,Gitte Neubauer,Nigel Ramsden,Gerard Drewes +23 more
TL;DR: This work revealed the selectivity with which 16 HDAC inhibitors target multiple HDAC complexes scaffolded by ELM-SANT domain subunits, including a novel mitotic deacetylase complex (MiDAC) and identified several non-HDAC targets for hydroxamate inhibitors.