G
Giulia E. Tyzack
Researcher at Francis Crick Institute
Publications - 34
Citations - 1184
Giulia E. Tyzack is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Biology & Amyotrophic lateral sclerosis. The author has an hindex of 11, co-authored 27 publications receiving 781 citations. Previous affiliations of Giulia E. Tyzack include University of Cambridge & University College London.
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Journal ArticleDOI
Three-dimensional Human iPSC-derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
S.M. Maffioletti,Shilpita Sarcar,Alexander B.H. Henderson,Ingra Mannhardt,Luca Pinton,Luca Pinton,Louise A. Moyle,Heather B. Steele-Stallard,Heather B. Steele-Stallard,Ornella Cappellari,K E Wells,Giulia Ferrari,Jamie S. Mitchell,Jamie S. Mitchell,Giulia E. Tyzack,Giulia E. Tyzack,Vassilios N. Kotiadis,Moustafa Khedr,M. Ragazzi,Weixin Wang,Michael R. Duchen,Rickie Patani,Rickie Patani,Peter S. Zammit,Dominic J. Wells,Thomas Eschenhagen,Francesco Tedesco +26 more
TL;DR: The generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including induced pluripoline stem cells (iPSCs) from patients with Duchenne, limb-girdle, and congenital muscular dystrophies is reported.
Journal ArticleDOI
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
Claire E. Hall,Zhi Yao,Minee L. Choi,Giulia E. Tyzack,Andrea Serio,Raphaëlle Luisier,Jasmine Harley,Elisavet Preza,Charles Arber,Sarah Crisp,P. Marc D. Watson,Dimitri M. Kullmann,Andrey Y. Abramov,Selina Wray,Russell Burley,Samantha H. Y. Loh,L. Miguel Martins,Molly M. Stevens,Nicholas M. Luscombe,Christopher R. Sibley,Andras Lakatos,Jernej Ule,Sonia Gandhi,Sonia Gandhi,Rickie Patani,Rickie Patani +25 more
TL;DR: Direct differentiation of induced pluripotent stem cells into highly enriched (> 85%) functional populations of spinal cord MNs and ACs is optimized and elucidates molecular events and cellular interplay that could guide future therapeutic strategies in ALS.
Journal ArticleDOI
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression
Giulia E. Tyzack,Sergey Sitnikov,Daniel Barson,Kerala L. Adams-Carr,Nike K. Lau,Jessica C. F. Kwok,Chao Zhao,Robin J.M. Franklin,Ragnhildur Thóra Káradóttir,James W. Fawcett,Andras Lakatos +10 more
TL;DR: It is demonstrated that TSP-1 is responsible for the remote AC-mediated recovery of excitatory synapses onto axotomized motor neurons in adult mice, providing new targets for neuroprotective therapies via optimizing AC-driven plasticity.
Journal ArticleDOI
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.
Giulia E. Tyzack,Giulia E. Tyzack,Raphaëlle Luisier,Doaa M Taha,Doaa M Taha,Jacob Neeves,Jacob Neeves,Miha Modic,Miha Modic,Jamie S. Mitchell,Jamie S. Mitchell,Ione Meyer,Linda Greensmith,Jia Newcombe,Jernej Ule,Jernej Ule,Nicholas M. Luscombe,Nicholas M. Luscombe,Nicholas M. Luscombe,Rickie Patani,Rickie Patani +20 more
TL;DR: FUS protein, previously thought to mislocalise only in patients with FUS mutations, is also mislocalised in many cases of sporadic ALS, and an underlying molecular mechanism for the mislocalisation is proposed.
Journal ArticleDOI
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS.
Raphaëlle Luisier,Giulia E. Tyzack,Giulia E. Tyzack,Claire E. Hall,Jamie S. Mitchell,Helen Devine,Doaa M Taha,Bilal Malik,Ione Meyer,Linda Greensmith,Jia Newcombe,Jernej Ule,Jernej Ule,Nicholas M. Luscombe,Nicholas M. Luscombe,Nicholas M. Luscombe,Rickie Patani,Rickie Patani +17 more
TL;DR: It is shown that aberrant IR occurs in ALS and nuclear loss of an RNA-binding protein called SFPQ is found as a new molecular hallmark in this devastating condition.