Gordon Fishell

TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.

TL;DR: This perspective emphasizes that the ultimate goal is to dispense with classification criteria and directly define interneuron types by function, and views them as elaborations of a much more finite group of developmentally specified cardinal classes that become further specialized as they mature.

TL;DR: A scheme of the neurogenesis cascade in the adult hippocampus is presented that includes a proposed "disposable stem cell" model and accounts for the disappearance of hippocampal neural stem cells, the appearance of new astrocytes, and the age-related decline in the production of new neurons.

TL;DR: Using genetic fate mapping, it is found that median eminence tanycytes generate newborn neurons, revealing a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.

TL;DR: This work employs a conditional loss-of-function approach to demonstrate that the transcription factor Nkx2-1 is required for the proper specification of specific interneuron subtypes and reveals a causal link between the embryonic genetic specification by Nkkx1 in progenitors and the functional attributes of their neuronal progeny in the mature nervous system.