Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Reads0
Chats0
TLDR
The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.Abstract:
An understanding of the diversity of cortical GABAergic interneurons is critical to understand the function of the cerebral cortex. Recent data suggest that neurons expressing three markers, the Ca2+-binding protein parvalbumin (PV), the neuropeptide somatostatin (SST), and the ionotropic serotonin receptor 5HT3a (5HT3aR) account for nearly 100% of neocortical interneurons. Interneurons expressing each of these markers have a different embryological origin. Each group includes several types of interneurons that differ in morphological and electrophysiological properties and likely have different functions in the cortical circuit. The PV group accounts for ∼40% of GABAergic neurons and includes fast spiking basket cells and chandelier cells. The SST group, which represents ∼30% of GABAergic neurons, includes the Martinotti cells and a set of neurons that specifically target layerIV. The 5HT3aR group, which also accounts for ∼30% of the total interneuronal population, is heterogeneous and includes all of the neurons that express the neuropeptide VIP, as well as an equally numerous subgroup of neurons that do not express VIP and includes neurogliaform cells. The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states and behavioral contexts.read more
Citations
More filters
Journal ArticleDOI
Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Bosiljka Tasic,Vilas Menon,Thuc Nghi Nguyen,Tae Kyung Kim,Tim Jarsky,Zizhen Yao,Boaz P. Levi,Lucas T. Gray,Staci A. Sorensen,Tim A. Dolbeare,Darren Bertagnolli,Jeff Goldy,Nadiya V. Shapovalova,Sheana Parry,Changkyu Lee,Kimberly A. Smith,Amy Bernard,Linda Madisen,Susan M. Sunkin,Michael Hawrylycz,Christof Koch,Hongkui Zeng +21 more
TL;DR: This work constructed a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing and identified 49 transcriptomic cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types.
Journal ArticleDOI
Reconstruction and Simulation of Neocortical Microcircuitry
Henry Markram,Henry Markram,Eilif Muller,Srikanth Ramaswamy,Michael W. Reimann,Marwan Abdellah,Carlos Aguado Sanchez,Anastasia Ailamaki,Lidia Alonso-Nanclares,Lidia Alonso-Nanclares,Nicolas Antille,Selim Arsever,Guy Antoine Atenekeng Kahou,Thomas K. Berger,Ahmet Bilgili,Nenad Buncic,Athanassia Chalimourda,Giuseppe Chindemi,Jean Denis Courcol,Fabien Delalondre,Vincent Delattre,Shaul Druckmann,Shaul Druckmann,Raphael Dumusc,James Dynes,Stefan Eilemann,Eyal Gal,Michael Gevaert,Jean Pierre Ghobril,Albert Gidon,Joe W. Graham,Anirudh Gupta,Valentin Haenel,Etay Hay,Thomas Heinis,Thomas Heinis,Juan Hernando,Michael L. Hines,Lida Kanari,Daniel Keller,John Kenyon,Georges Khazen,Yihwa Kim,James G. King,Zoltán F. Kisvárday,Pramod Kumbhar,Sebastien Lasserre,Jean Vincent Le Bé,Bruno R. C. Magalhães,Angel Merchán-Pérez,Angel Merchán-Pérez,Julie Meystre,Benjamin Roy Morrice,Jeffrey Muller,Alberto Muñoz-Céspedes,Alberto Muñoz-Céspedes,Shruti Muralidhar,Keerthan Muthurasa,Daniel Nachbaur,Taylor Howard Newton,Max Nolte,Aleksandr Ovcharenko,Juan Palacios,Luis Pastor,Rodrigo Perin,Rajnish Ranjan,Rajnish Ranjan,Imad Riachi,José-Rodrigo Rodríguez,José-Rodrigo Rodríguez,Juan Luis Riquelme,Christian Rössert,Konstantinos Sfyrakis,Ying Shi,Ying Shi,Julian C. Shillcock,Gilad Silberberg,Ricardo Silva,Farhan Tauheed,Martin Telefont,Maria Toledo-Rodriguez,Thomas Tränkler,Werner Van Geit,Jafet Villafranca Diaz,Richard Walker,Yun Wang,Yun Wang,Stefano M. Zaninetta,Javier DeFelipe,Javier DeFelipe,Sean Hill,Idan Segev,Felix Schürmann +92 more
TL;DR: A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms.
Journal ArticleDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Lucas T. Graybuck,Kimberly A. Smith,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Sheana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Heather A. Sullivan,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +48 more
TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
Journal ArticleDOI
A survey of human brain transcriptome diversity at the single cell level
Spyros Darmanis,Steven A. Sloan,Ye Zhang,Martin Enge,Christine Caneda,Lawrence M. Shuer,Melanie Hayden Gephart,Ben A. Barres,Stephen R. Quake +8 more
TL;DR: The first, to the authors' knowledge, single cell whole transcriptome analysis of human adult cortical samples is described, establishing an experimental and analytical framework with which the complexity of the human brain can be dissected on the single cell level.
Journal ArticleDOI
Cortical interneurons that specialize in disinhibitory control
Hyun Jae Pi,Balázs Hangya,Balázs Hangya,Duda Kvitsiani,Joshua I. Sanders,Z. Josh Huang,Adam Kepecs +6 more
TL;DR: A class of interneurons that express vasoactive intestinal polypeptide (VIP) mediates disinhibitory control in multiple areas of neocortex and is recruited by reinforcement signals, revealing a specific cell type and microcircuit underlying disinhibited control in cortex and demonstrating that it is activated under specific behavioural conditions.
References
More filters
Journal ArticleDOI
Interneurons of the neocortical inhibitory system.
TL;DR: This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.
Journal ArticleDOI
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Jessica A. Cardin,Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Ulf Knoblich,Feng Zhang,Karl Deisseroth,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai,Christopher I. Moore +11 more
TL;DR: The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
Journal ArticleDOI
Critical period plasticity in local cortical circuits.
TL;DR: The reactivation of this process, and subsequent recovery of function in conditions such as amblyopia, can now be studied with realistic circuit models that might generalize across systems.
Journal ArticleDOI
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
TL;DR: Experimental analysis in the hippocampus and the neocortex and computational analysis suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.
Journal ArticleDOI
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations.
TL;DR: The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior.
Related Papers (5)
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
Giorgio A. Ascoli,Lidia Alonso-Nanclares,Stewart A. Anderson,German Barrionuevo,Ruth Benavides-Piccione,Andreas Burkhalter,György Buzsáki,Bruno Cauli,Javier DeFelipe,Alfonso Fairén,Dirk Feldmeyer,Gord Fishell,Yves Frégnac,Tamás F. Freund,Daniel Gardner,Esther P. Gardner,Jesse H. Goldberg,Moritz Helmstaedter,Shaul Hestrin,Fuyuki Karube,Zoltán F. Kisvárday,Bertrand Lambolez,David A. Lewis,Oscar Marín,Henry Markram,Alberto Muñoz,Adam M. Packer,Carl C.H. Petersen,Kathleen S. Rockland,Jean Rossier,Bernardo Rudy,Peter Somogyi,Jochen F. Staiger,Gábor Tamás,Alex M. Thomson,Maria Toledo-Rodriguez,Yun Wang,David C. West,Rafael Yuste +38 more