Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Daniel A. Lee,Joseph L. Bedont,Thomas Pak,Hong Wang,Juan Song,Ana L. Miranda-Angulo,Ana L. Miranda-Angulo,Vani Takiar,Vanessa Charubhumi,Francesca Balordi,Hirohide Takebayashi,Susan Aja,Eric C. Ford,Gordon Fishell,Seth Blackshaw +14 more
TLDR
Using genetic fate mapping, it is found that median eminence tanycytes generate newborn neurons, revealing a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.Abstract:
Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons Blocking this neurogenesis altered the weight and metabolic activity of adult mice These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolismread more
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Physiology of astroglia
TL;DR: Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
Journal ArticleDOI
Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity.
TL;DR: Single-cell RNA sequencing results of adult mouse hypothalamus are reported, which defines 11 non-neuronal and 34 neuronal cell clusters with distinct transcriptional signatures andalyses of cell-type-specific transcriptomes reveal gene expression dynamics underlying oligodendrocyte differentiation and tanycyte subtypes.
Journal ArticleDOI
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Yalin Zhang,Min Soo Kim,Baosen Jia,Jingqi Yan,Juan Pablo Zuniga-Hertz,Cheng Han,Dongsheng Cai +6 more
TL;DR: Development of several mouse models in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1 are ablated shows that ageing in mice started with a substantial loss of these hypothalamic cells, and ageing speed is substantially controlled by hypothalamicstem cells, partially through the release of exosomal miRNAs.
Journal ArticleDOI
IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes.
TL;DR: Adult htNSCs are important for the central regulation of metabolic physiology, and IKKβ/NF-κB-mediated impairment of adult ht NSCs is a critical neurodegenerative mechanism for obesity and related diabetes.
Journal ArticleDOI
Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting.
Fanny Langlet,Barry E. Levin,Barry E. Levin,Serge Luquet,Massimiliano Mazzone,Andrea Messina,Andrea Messina,Ambrose A. Dunn-Meynell,Ambrose A. Dunn-Meynell,Eglantine Balland,Eglantine Balland,Amélie Lacombe,Danièle Mazur,Danièle Mazur,Peter Carmeliet,Sebastien G. Bouret,Vincent Prevot,Vincent Prevot,Bénédicte Dehouck +18 more
TL;DR: The decrease in blood glucose levels during fasting alters the structural organization of this blood-hypothalamus barrier, resulting in the improved access of metabolic substrates to the arcuate nucleus, and shows a hitherto unappreciated role for tanycytes and the permeable microvessels associated with them in the adaptive metabolic response to fasting.
References
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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Shankar Srinivas,Tomoko Watanabe,Chyuan-Sheng Lin,Chris M William,Yasuto Tanabe,Thomas M. Jessell,Frank Costantini +6 more
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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Michael A. Cowley,James L. Smart,Marcelo Rubinstein,Marcelo G. Cerdán,Sabrina Diano,Tamas L. Horvath,Roger D. Cone,Malcolm J. Low +7 more
TL;DR: An integrated model of leptin action and neuronal architecture in the arcuate nucleus of the hypothalamus is proposed and it is shown that melanocortin peptides have an autoinhibitory effect on this circuit.
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Neurogenesis in the hypothalamus of adult mice: potential role in energy balance.
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