G
Gottfried Brem
Researcher at University of Veterinary Medicine Vienna
Publications - 454
Citations - 17130
Gottfried Brem is an academic researcher from University of Veterinary Medicine Vienna. The author has contributed to research in topics: Gene & Population. The author has an hindex of 65, co-authored 448 publications receiving 15998 citations. Previous affiliations of Gottfried Brem include University of Vienna & University of Natural Resources and Life Sciences, Vienna.
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Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
TL;DR: It is suggested that BDNF might have a functional role in the expression of LTP in the hippocampus, and the magnitude of the potentiation, as well as the percentage of cases in which LTP could be induced successfully, was clearly affected.
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A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen
TL;DR: The results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments.
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Disruption of the CNTF gene results in motor neuron degeneration.
TL;DR: It is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.
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Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice
Marina Karaghiosoff,Hans Neubauer,Caroline Lassnig,Pavel Kovarik,Heike Schindler,Hanspeter Pircher,Barbara McCoy,Christian Bogdan,Thomas Decker,Gottfried Brem,Klaus Pfeffer,Mathias Müller,Mathias Müller +12 more
TL;DR: Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge, which imply a selective contribution of Tyk2 to the signals triggered by various biological stimuli and cytokine receptors.
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Efficient transgenesis in farm animals by lentiviral vectors
Andreas Hofmann,Barbara Kessler,Sonja Ewerling,Myriam Weppert,Barbara Vogg,Harald Ludwig,Miodrag Stojkovic,Marc Boelhauve,Gottfried Brem,Eckhard Wolf,Alexander Pfeifer +10 more
TL;DR: Tissue‐specific transgene expression was achieved by infecting porcine embryos with lentiviral vectors containing the human keratin K14 promoter (LV‐K14).