Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice
Marina Karaghiosoff,Hans Neubauer,Caroline Lassnig,Pavel Kovarik,Heike Schindler,Hanspeter Pircher,Barbara McCoy,Christian Bogdan,Thomas Decker,Gottfried Brem,Klaus Pfeffer,Mathias Müller,Mathias Müller +12 more
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TLDR
Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge, which imply a selective contribution of Tyk2 to the signals triggered by various biological stimuli and cytokine receptors.About:
This article is published in Immunity.The article was published on 2000-10-01 and is currently open access. It has received 419 citations till now. The article focuses on the topics: Janus kinase 1 & Cytokine receptor.read more
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Nitric oxide and the immune response
TL;DR: Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications.
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Interferons, immunity and cancer immunoediting.
TL;DR: The roles of the IFNs are discussed, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting.
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Signaling through the JAK/STAT pathway, recent advances and future challenges.
TL;DR: Significant progress has been made in the characterization of the JAK/STAT signaling cascade, including the identification of multiple STATs and regulatory proteins, and the solution of the crystal structure of two STATs has and will continue to facilitate the understanding of how STATs function.
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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.
TL;DR: This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research.
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The JAK-STAT Signaling Pathway: Input and Output Integration
TL;DR: This work discusses how diverse outcomes in gene expression result from regulatory events that effect the JAK1-STAT3 pathway, common to both receptors and considers how the suppressor of cytokine signaling (SOCS) proteins regulate the quality and quantity of STAT signals from cytokine receptors.
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Nitric oxide and macrophage function
TL;DR: Although the high-output NO pathway probably evolved to protect the host from infection, suppressive effects on lymphocyte proliferation and damage to other normal host cells confer upon NOS2 the same protective/destructive duality inherent in every other major component of the immune response.
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How cells respond to interferons
TL;DR: The Janus kinases and signal transducers and activators of transcription, and many of the interferon-induced proteins, play important alternative roles in cells, raising interesting questions as to how the responses to the interFERons intersect with more general aspects of cellular physiology and how the specificity of cytokine responses is maintained.
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STATs and Gene Regulation
TL;DR: The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
Journal Article
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
TL;DR: Testing as a sole agent, IFN-gamma was the only one of the 12 cytokines capable of inducing both NO2- and H2O2 release and the pathways leading to secretion of H2 O2 and No2- are independent.
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Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity
TL;DR: IL-12 represents a functional bridge between the early nonspecific innate resistance and the subsequent antigen-specific adaptive immunity in the innate resistance/adaptive immune response to infection.