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Graeme Milligan

Researcher at University of Glasgow

Publications -  570
Citations -  32250

Graeme Milligan is an academic researcher from University of Glasgow. The author has contributed to research in topics: Receptor & G protein. The author has an hindex of 88, co-authored 556 publications receiving 30032 citations. Previous affiliations of Graeme Milligan include University of Leicester & Autonomous University of Barcelona.

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Book ChapterDOI

Experimental Challenges to Targeting Poorly Characterized GPCRs: Uncovering the Therapeutic Potential for Free Fatty Acid Receptors

Brian D. Hudson, +2 more
- 01 Jan 2011 - 
TL;DR: Even once a GPCR has been deorphanized, the receptor typically is still poorly characterized in terms of its pharmacology and biological functions, presenting a unique set of experimental challenges in order to define its therapeutic potential.
Journal ArticleDOI

Wortmannin-sensitive Activation of p70 by Endogenous and Heterologously Expressed G-coupled Receptors

Moira A. Wilson, +3 more
- 12 Apr 1996 - 
TL;DR: Data indicate that p70 is regulatable by G-coupled receptor agonists in a pertussis toxin-sensitive fashion in Rat-1 fibroblasts and that activation of p70 by such agents appears to involve an isoform of PI 3-kinase.
Journal ArticleDOI

Visualization of Agonist-induced Association and Trafficking of Green Fluorescent Protein-tagged Forms of Both β-Arrestin-1 and the Thyrotropin-releasing Hormone Receptor-1

D. A. Groarke, +3 more
- 13 Aug 1999 - 
TL;DR: The capacity of β-arrestin-1-GFP to interact with the rat TRHR-1 and directly visualizes their recruitment from cytoplasm and plasma membrane respectively into overlapping, intracellular vesicles in an agonist-dependent manner is demonstrated.
Journal ArticleDOI

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

Elisabeth Christiansen, +10 more
- 13 Jul 2012 - 
TL;DR: The effects of a mesylpropoxy appendage significantly lowers lipophilicity and improves metabolic stability while preserving potency, resulting in discovery of the potent FFA1 agonist TUG-469.
Journal ArticleDOI

Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development.

Charles W. Luetje, +5 more
- 28 Jul 1987 - 
TL;DR: The levels of several components of the cholinergic neuroeffector pathway are regulated in a tissue-specific manner at a time that coincides with the onset of functional parasympathetic innervation of the embryonic chicken heart.