Graeme Milligan

TL;DR: These studies indicate that gonadotrophin-releasing hormone receptor agonist-mediated down-regulation of Gq alpha/G11 alpha is a reflection of enhanced proteolysis of the activated G proteins.

TL;DR: The nature of melatonin receptor‐G‐protein coupling in ovine pars tuberalis (PT) cells of the pituitary was addressed using cholera (CTX) and pertussis (PTX) toxins using 32P‐NAD in the presence of CTX radiolabelled several substrates including 44, 51, and 60 kD proteins.

TL;DR: These studies demonstrate that marked species selectivity of ligands at GPR35 is not restricted to agonists and considerable care is required to select appropriate ligands to explore the function of G PR35 in nonhuman cells and tissues.

TL;DR: It is demonstrated that CXCR1 is able to both homodimerizing and heterodimerize with the CX CR2 receptor and that the relative affinity of these interactions suggests that with coexpression of these two GPCRs a random mixture of homo- andheterodimers will be present.

TL;DR: The data demonstrate that the palmitoylation status of the cysteine residues at positions 9 and 10 in murine G11 alpha plays a central role in defining membrane association of this G-protein and indicate that much of the particulate fraction of the expressed palMIToylation-resistant mutants is likely to represent non-functional rather than correctly folded protein.