G
Graeme Milligan
Researcher at University of Glasgow
Publications - 570
Citations - 32250
Graeme Milligan is an academic researcher from University of Glasgow. The author has contributed to research in topics: Receptor & G protein. The author has an hindex of 88, co-authored 556 publications receiving 30032 citations. Previous affiliations of Graeme Milligan include University of Leicester & Autonomous University of Barcelona.
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Journal ArticleDOI
Generation and Analysis of Constitutively Active and Physically Destabilized Mutants of the Human β1-Adrenoceptor
TL;DR: Clear resolution between receptor constitutive activity and ligand suppression of receptor instability can be obtained for mutant beta-adrenoceptors, and potential inverse agonists do not function equally at phenotypically apparently equivalent CAM receptors.
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Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy
Steffen V F Hansen,Elisabeth Christiansen,Christian Urban,Brian D. Hudson,Claire J. Stocker,Maria E Due-Hansen,Ed Wargent,Bharat Shimpukade,Reinaldo Almeida,Christer S. Ejsing,Michael A. Cawthorne,Matthias U. Kassack,Graeme Milligan,Trond Ulven +13 more
TL;DR: 24 is described, a potent FFA1 agonist with low lipophilicity and very high ligand efficiency that exhibit robust glucose lowering effect and is described as a potential new treatment for type 2 diabetes.
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Dynamic protein acylation and the regulation of localization and function of signal-transducing proteins.
C. S. Jackson,P. Zlatkine,C. Bano,Panagiotis S. Kabouridis,B. Mehul,Marco Parenti,Graeme Milligan,Steven C. Ley,Anthony I. Magee +8 more
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Action of Pasteurella multocida toxin on Gαq is persistent and independent of interaction with G-protein-coupled receptors
TL;DR: The data indicate that activation of Galpha (q) by PMT is persistent and independent of a functional interaction of G(q) with G-protein-coupled receptors.
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The molecular basis of oligomeric organization of the human M3 muscarinic acetylcholine receptor.
María José Varela Liste,Gianluigi Caltabiano,Richard J. Ward,Elisa Alvarez-Curto,Sara Marsango,Graeme Milligan +5 more
TL;DR: Observations suggest that organization as a tetramer may occur before plasma membrane delivery and may be a key step in cellular quality control assessment.