G
Graeme Milligan
Researcher at University of Glasgow
Publications - 570
Citations - 32250
Graeme Milligan is an academic researcher from University of Glasgow. The author has contributed to research in topics: Receptor & G protein. The author has an hindex of 88, co-authored 556 publications receiving 30032 citations. Previous affiliations of Graeme Milligan include University of Leicester & Autonomous University of Barcelona.
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Journal ArticleDOI
Tailoring cAMP-signalling responses through isoform multiplicity
Miles D. Houslay,Graeme Milligan +1 more
TL;DR: Multiple forms of cAMP phosphodiesterases, adenylate cyclase and protein kinase A allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for its dynamic adjustment.
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G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
Evi Kostenis,Graeme Milligan,Arthur Christopoulos,Carlos F. Sánchez-Ferrer,Silvia Heringer-Walther,Patrick M. Sexton,Florian Gembardt,Elaine Kellett,Lene Martini,Patrick Vanderheyden,Heinz-Peter Schultheiss,Thomas Walther +11 more
TL;DR: It is demonstrated that Mas can hetero-oligomerize with the AT1 receptor and by so doing inhibit the actions of angiotensin II, a novel demonstration that a G-protein–coupled receptor acts as a physiological antagonist of a previously characterized receptor.
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Building a new conceptual framework for receptor heteromers
Sergi Ferré,Ruben Baler,Michel Bouvier,Marc G. Caron,Lakshmi A. Devi,Thierry Durroux,Kjell Fuxe,Susan R. George,Jonathan A. Javitch,Martin J. Lohse,Ken Mackie,Graeme Milligan,Kevin D. G. Pfleger,Jean-Philippe Pin,Nora D. Volkow,Maria Waldhoer,Amina S. Woods,Rafael Franco +17 more
TL;DR: This commentary considers research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.
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Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.
Paul K. Goldsmith,Peter Gierschik,Graeme Milligan,C G Unson,R Vinitsky,Harry L. Malech,Allen M. Spiegel +6 more
TL;DR: Antisera AS/6 and 7 react on immunoblots with purified transducin-alpha and Gi alpha with proteins of 40-41 kDa in all tissues tested, distinguishing between the major pertussis toxin substrates of brain and neutrophil and tentatively identify the latter as Gi alpha-2.
Journal ArticleDOI
International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions
TL;DR: A comprehensive overview of the current understanding of the pharmacology and physiological role of the G protein-coupled receptors activated by free fatty acids is provided.