G
Graeme Milligan
Researcher at University of Glasgow
Publications - 570
Citations - 32250
Graeme Milligan is an academic researcher from University of Glasgow. The author has contributed to research in topics: Receptor & G protein. The author has an hindex of 88, co-authored 556 publications receiving 30032 citations. Previous affiliations of Graeme Milligan include University of Leicester & Autonomous University of Barcelona.
Papers
More filters
Journal ArticleDOI
A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization
TL;DR: It is now firmly established that G protein‐coupled receptor hetero‐dimers exist and function as dimers or, potentially, even within higher‐order structures.
Journal ArticleDOI
BRET analysis of GPCR oligomerization: newer does not mean better.
Michel Bouvier,Nikolaus Heveker,Ralf Jockers,Ralf Jockers,Ralf Jockers,Stefano Marullo,Stefano Marullo,Stefano Marullo,Graeme Milligan +8 more
TL;DR: A “rigorous” treatment of bioluminescence resonance energy transfer data to distinguish random (non-specific) from true oligomeric protein interactions and no direct conclusion can be drawn on the amount of dimers simply based on the maximal BRET signals observed.
Journal ArticleDOI
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
Johannes Schmidt,Nicola J. Smith,Elisabeth Christiansen,Irina G. Tikhonova,Manuel Grundmann,Brian D. Hudson,Richard J. Ward,Christel Drewke,Graeme Milligan,Evi Kostenis,Trond Ulven +10 more
TL;DR: Selective activation of FFA2 via the orthosteric site is achievable with rather small ligands, a finding with significant implications for the rational design of therapeutic compounds selectively targeting the SCFA receptors.
Journal ArticleDOI
Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3
TL;DR: An “ionic lock” between extracellular loop 2 and the ligand binding pocket regulates constitutive activity and SCFA potency in FFA2 and FFA3 orthologs.
Journal ArticleDOI
Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications
TL;DR: Agonist-induced reduction in cellular G protein levels can provide one mechanism for the development of sustained heterologous desensitization and include both second messenger-dependent and -independent enhanced protein degradation.