Graeme Milligan

TL;DR: In this paper, a single residue present within the third transmembrane domain (TM) of S1P receptors is thought to determine ligand selectivity; replacement of the naturally occurring glutamic acid with glutamine (present at this position in the LPA receptors) has previously been shown to change the specificity of S 1P1 from S 1 p to 18:1 LPA.

TL;DR: The physiological and pathological expression profile of G PR84 is considered and, in the absence of direct structural information, recent developments and use of GPR84 pharmacological tool compounds to study its broader role and biology are considered.

TL;DR: An antiserum (13CB) was generated against a synthetic peptide, HDNLKQLMLQ, which is predicted to represent the C‐terminal decapeptide of the α subunit of the novel G‐protein, G13, and showed minimal ability to recognize peptides which represent the equivalent regions of the pertussis toxin‐insensitive G‐proteins.

TL;DR: A single population of beta-adrenergic receptors apparently interacts with distinct G-proteins to activate different effectors, and the stoichiometries of the receptor-G-protein-effector interactions are similar for both second-messenger responses and the data are discussed in terms of the different efficacies observed for each response.

TL;DR: Results suggest that D3 protomers can interact with each other via at least two distinct interfaces and are consistent with the D3 receptor adopting a β1-adrenoreceptor-like quaternary arrangement.