G
Grégory Giannone
Researcher at Centre national de la recherche scientifique
Publications - 65
Citations - 7033
Grégory Giannone is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Focal adhesion & Integrin. The author has an hindex of 31, co-authored 61 publications receiving 6109 citations. Previous affiliations of Grégory Giannone include University of Bordeaux & Columbia University.
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Journal ArticleDOI
Periodic Lamellipodial Contractions Correlate with Rearward Actin Waves
Grégory Giannone,Benjamin J. Dubin-Thaler,Hans-Günther Döbereiner,Nelly Kieffer,Anne R. Bresnick,Michael P. Sheetz +5 more
TL;DR: It is proposed that an actin bound, contraction-activated signaling complex is transported locally from the tip to the base of the lamellipodium, activating the next contraction/extension cycle.
Journal ArticleDOI
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
Matthew J. Paszek,Christopher C. DuFort,Olivier Rossier,Russell Bainer,Janna K. Mouw,Kamil Godula,Jason E. Hudak,Jonathon N. Lakins,Amanda C. Wijekoon,Luke Cassereau,Matthew G. Rubashkin,Mark Jesus M. Magbanua,Kurt S. Thorn,Michael W. Davidson,Hope S. Rugo,John W. Park,Daniel A. Hammer,Grégory Giannone,Carolyn R. Bertozzi,Valerie M. Weaver +19 more
TL;DR: A bulky glycocalyx is a feature of tumour cells that could foster metastasis by mechanically enhancing cell-surface receptor function by increasing integrin adhesion and signalling.
Journal ArticleDOI
Lamellipodial Actin Mechanically Links Myosin Activity with Adhesion-Site Formation
Grégory Giannone,Benjamin J. Dubin-Thaler,Olivier Rossier,Yunfei Cai,Oleg Y. Chaga,Guoying Jiang,William Beaver,Hans-Günther Döbereiner,Yoav Freund,Gary G. Borisy,Michael P. Sheetz +10 more
TL;DR: Actin polymerization periodically builds a mechanical link, the lamellipodium, connecting myosin motors with the initiation of adhesion sites, suggesting that the major functions driving motility are coordinated by a biomechanical process.
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Super-resolution imaging reveals that AMPA receptors inside synapses are dynamically organized in nanodomains regulated by PSD95.
Deepak T. Nair,Eric Hosy,Eric Hosy,Jennifer D. Petersen,Jennifer D. Petersen,Audrey Constals,Audrey Constals,Grégory Giannone,Grégory Giannone,Daniel Choquet,Daniel Choquet,Jean-Baptiste Sibarita,Jean-Baptiste Sibarita +12 more
TL;DR: The observation that AMPARs are highly concentrated in nanodomains, instead of diffusively distributed in the PSD as generally thought, has important consequences on the understanding of excitatory neurotransmission.
Journal ArticleDOI
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin
TL;DR: It is suggested that talin1 initially forms a molecular slip bond between closely packed fibronectin–integrin complexes and the actin cytoskeleton, which can apply a low level of force to fibronECTin until many bonds form or a signal is received to activate a force response.