G
Guangbin Xia
Researcher at University of New Mexico
Publications - 48
Citations - 2708
Guangbin Xia is an academic researcher from University of New Mexico. The author has contributed to research in topics: Spinocerebellar ataxia & Ataxia. The author has an hindex of 27, co-authored 48 publications receiving 2290 citations. Previous affiliations of Guangbin Xia include Tokyo Medical and Dental University & University of Florida.
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Muscleblind-like 2-Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy
Konstantinos Charizanis,Kuang-Yung Lee,Kuang-Yung Lee,Ranjan Batra,Marianne Goodwin,Chaolin Zhang,Yuan Yuan,Lily Shiue,Melissa S. Cline,Marina M. Scotti,Guangbin Xia,Ashok V. Kumar,Tetsuo Ashizawa,H. Brent Clark,Takashi Kimura,Masanori P. Takahashi,Harutoshi Fujimura,Kenji Jinnai,Hiroo Yoshikawa,Mário Gomes-Pereira,Geneviève Gourdon,Noriaki Sakai,Seiji Nishino,Thomas C. Foster,Manuel Ares,Robert B. Darnell,Maurice S. Swanson +26 more
TL;DR: It is reported that Mbnl2 knockout mice develop several DM-associated central nervous system (CNS) features including abnormal REM sleep propensity and deficits in spatial memory.
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Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
Ranjan Batra,David A. Nelles,Elaine Pirie,Steven M. Blue,Ryan J. Marina,Harrison Wang,Isaac A. Chaim,James D. Thomas,Nigel Zhang,Vu T. Nguyen,Stefan Aigner,Sebastian Markmiller,Guangbin Xia,Kevin D. Corbett,Kevin D. Corbett,Maurice S. Swanson,Gene W. Yeo +16 more
TL;DR: RNA-targeting Cas9 (RCas9) reverses hallmark features of disease including elimination of RNA foci among all conditions studied, reduction of polyglutamine protein products, relocalization of repeat-bound proteins to resemble healthy controls, and efficient reversal of DM1-associated splicing abnormalities in patient myotubes.
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Receptor Tyrosine Kinase EphB4 Is a Survival Factor in Breast Cancer
S. Ram Kumar,Jasvinder A. Singh,Guangbin Xia,Valery Krasnoperov,Loubna Hassanieh,Eric J. Ley,Jeffrey S. Scehnet,Neil G. Kumar,Debra Hawes,Michael F. Press,Fred A. Weaver,Parkash S. Gill +11 more
TL;DR: The data indicate that biologically active EphB4 functions as a survival factor in breast cancer and is a novel target for therapy.
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Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops.
Rizwan Masood,Ajay Kundra,Sutao Zhu,Guangbin Xia,Pierluigi Scalia,D. Lynne Smith,Parkash S. Gill +6 more
TL;DR: Results indicate that targeting VEGF and V EGF‐C simultaneously may be an effective therapeutic approach for malignant mesothelioma.
Journal ArticleDOI
EphB4 Expression and Biological Significance in Prostate Cancer
Guangbin Xia,S. Ram Kumar,Rizwan Masood,Sutao Zhu,Ramchandra Reddy,Valery Krasnoperov,David I. Quinn,Susan M. Henshall,Robert L. Sutherland,Jacek Pinski,Siamak Daneshmand,Maurizio Buscarini,John P. Stein,Chen Zhong,Daniel Broek,Pradip Roy-Burman,Parkash S. Gill +16 more
TL;DR: A role for EphB4 in prostate cancer is shown and a rationale to study E phB4 for diagnostic, prognostic, and therapeutic applications is provided.