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Irina Savitcheva
Researcher at Karolinska University Hospital
Publications - 43
Citations - 5735
Irina Savitcheva is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Dementia & Internal medicine. The author has an hindex of 14, co-authored 35 publications receiving 5269 citations. Previous affiliations of Irina Savitcheva include Karolinska Institutet & Uppsala University Hospital.
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Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TL;DR: The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
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Two-year follow-up of amyloid deposition in patients with Alzheimer's disease.
Henry Engler,Anton Forsberg,Ove Almkvist,Gunnar Blomquist,Emma Larsson,Irina Savitcheva,Anders Wall,Anna Ringheim,Bengt Långström,Agneta Nordberg +9 more
TL;DR: Relatively stable PIB retention after 2 years of follow-up in patients with mild Alzheimer's disease suggests that amyloid deposition in the brain reaches a plateau by the early clinical stages of Alzheimer’s disease and therefore may precede a decline in rCMRGlc and cognition.
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In vivo amyloid imaging with PET in frontotemporal dementia.
Henry Engler,Alexander Santillo,Shu Xia Wang,Maria Lindau,Irina Savitcheva,Agneta Nordberg,Agneta Nordberg,Lars Lannfelt,Bengt Langstrom,Bengt Langstrom,Lena Kilander +10 more
TL;DR: PIB could potentially aid in differentiating between FTD and AD, and eight FTD patients showed significantly lower PIB retention compared to AD in frontal, parietal, temporal, temporal and occipital cortices.
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In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography
Susan Learned-Coughlin,Mats Bergström,Irina Savitcheva,John A. Ascher,Virginia D. Schmith,Bengt Långström +5 more
TL;DR: Bupropion and its metabolites induced a low occupancy of the striatal DAT over 24 hours under conditions of steady-state oral dosing with therapeutic doses of bupropion SR, consistent with the hypothesis that dopamine reuptake inhibition may be responsible in part for the therapeutic effects of the drug.
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Imaging in-vivo tau pathology in Alzheimer’s disease with THK5317 PET in a multimodal paradigm
Konstantinos Chiotis,Laure Saint-Aubert,Irina Savitcheva,Vesna Jelic,Pia Andersen,My Jonasson,My Jonasson,Jonas Eriksson,Jonas Eriksson,Mark Lubberink,Ove Almkvist,Ove Almkvist,Ove Almkvist,Anders Wall,Anders Wall,Gunnar Antoni,Gunnar Antoni,Agneta Nordberg,Agneta Nordberg +18 more
TL;DR: The tau-specific PET tracer [18F]THK5317 images in vivo show the expected regional distribution of tau pathology, which contrasts with the different patterns of hypometabolism and amyloid-beta deposition.