J
James R. Elmore
Researcher at Geisinger Medical Center
Publications - 92
Citations - 4412
James R. Elmore is an academic researcher from Geisinger Medical Center. The author has contributed to research in topics: Abdominal aortic aneurysm & Aortic aneurysm. The author has an hindex of 33, co-authored 87 publications receiving 3783 citations. Previous affiliations of James R. Elmore include Pennsylvania State University & Mayo Clinic.
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Journal ArticleDOI
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
Frederick E. Dewey,Michael F. Murray,John D. Overton,Lukas Habegger,Joseph B. Leader,Samantha N. Fetterolf,Colm O'Dushlaine,Cristopher V. Van Hout,Jeffrey Staples,Claudia Gonzaga-Jauregui,Raghu Metpally,Sarah A. Pendergrass,Monica A. Giovanni,H. Lester Kirchner,Suganthi Balasubramanian,Noura S. Abul-Husn,Dustin N. Hartzel,Daniel R. Lavage,Korey A. Kost,Jonathan S. Packer,Alexander Lopez,John Penn,Semanti Mukherjee,Nehal Gosalia,Manoj Kanagaraj,Alexander H. Li,Lyndon J. Mitnaul,Lance J. Adams,Thomas N. Person,Kavita Praveen,Anthony Marcketta,Matthew S. Lebo,Christina Austin-Tse,Heather Mason-Suares,Shannon Bruse,Scott Mellis,Robert H. Phillips,Neil Stahl,Andrew J. Murphy,Aris N. Economides,Kimberly A. Skelding,Christopher D. Still,James R. Elmore,Ingrid B. Borecki,George D. Yancopoulos,F. Daniel Davis,William A. Faucett,Omri Gottesman,Marylyn D. Ritchie,Alan R. Shuldiner,Jeffrey G. Reid,David H. Ledbetter,Aris Baras,David J. Carey +53 more
TL;DR: Exome-wide association analyses of EHR-derived lipid values, newly implicating rare predicted LoFs, and deleterious missense variants in G6PC in association with triglyceride levels found associations supporting the majority of therapeutic targets for lipid lowering.
Journal ArticleDOI
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Journal ArticleDOI
Restenosis after carotid artery stenting and endarterectomy: a secondary analysis of CREST, a randomised controlled trial
Brajesh K. Lal,Kirk W. Beach,Gary S. Roubin,Helmi L. Lutsep,Wesley S. Moore,Mahmoud B. Malas,David Chiu,Nicole R. Gonzales,J. Lee Burke,Michael Rinaldi,James R. Elmore,Fred A. Weaver,Craig R. Narins,Malcolm Foster,Kim J. Hodgson,Alexander D. Shepard,James F. Meschia,Robert O. Bergelin,Jenifer H. Voeks,George Howard,Thomas G. Brott +20 more
TL;DR: The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) as discussed by the authors was designed to compare the composite endpoint of restenosis or occlusion.
Journal ArticleDOI
Understanding the pathogenesis of abdominal aortic aneurysms
TL;DR: It is expected that large genetic, genomic, epigenetic, proteomic and metabolomic studies will be undertaken by international consortia to identify additional risk factors and biomarkers, and to enhance the understanding of the pathobiology of AAA.
Journal ArticleDOI
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
Solveig Gretarsdottir,Annette F. Baas,Gudmar Thorleifsson,Hilma Holm,Martin den Heijer,Jean-Paul P. M. de Vries,Steef Kranendonk,Clark J. Zeebregts,Steven M.M. van Sterkenburg,Robert H. Geelkerken,Andre M. van Rij,Michael J.A. Williams,A.P.M. Boll,Jelena Kostic,Adalbjorg Jonasdottir,Aslaug Jonasdottir,G. Bragi Walters,Gisli Masson,Patrick Sulem,Jona Saemundsdottir,Magali Mouy,Kristinn P. Magnusson,Gerard Tromp,James R. Elmore,Natzi Sakalihasan,Raymond Limet,Jean-Olivier Defraigne,Robert E. Ferrell,Antti Ronkainen,Ynte M. Ruigrok,Cisca Wijmenga,Diederick E. Grobbee,Svati H. Shah,Christopher B. Granger,Arshed A. Quyyumi,Viola Vaccarino,Riyaz S. Patel,Riyaz S. Patel,A. Maziar Zafari,Allan I. Levey,Harland Austin,Domenico Girelli,Pier Franco Pignatti,Oliviero Olivieri,Nicola Martinelli,Giovanni Malerba,Elisabetta Trabetti,Lewis C. Becker,Diane M. Becker,Muredach P. Reilly,Daniel J. Rader,Thomas Mueller,Benjamin Dieplinger,Meinhard Haltmayer,Sigitas Urbonavicius,Bengt Lindblad,Anders Gottsäter,Eleonora Gaetani,Roberto Pola,Roberto Pola,Philip S. Wells,Marc A. Rodger,Melissa A. Forgie,Nicole Langlois,Javier Corral,Vicente Vicente,Jordi Fontcuberta,Francisco España,Niels Grarup,Torben Jørgensen,Daniel R. Witte,Torben Hansen,Oluf Pedersen,Katja K.H. Aben,Jacqueline de Graaf,Suzanne Holewijn,Lasse Folkersen,Anders Franco-Cereceda,Per Eriksson,David A. Collier,Hreinn Stefansson,Valgerdur Steinthorsdottir,Thorunn Rafnar,Einar M. Valdimarsson,Hulda B Magnadottir,Sigurlaug Sveinbjörnsdóttir,Isleifur Olafsson,Magnus K. Magnusson,Robert Palmason,Vilhelmina Haraldsdottir,Karl Andersen,Pall T. Onundarson,Gudmundur Thorgeirsson,Lambertus A. Kiemeney,Janet T. Powell,David J. Carey,Helena Kuivaniemi,Jes S. Lindholt,Gregory T. Jones,Augustine Kong,Jan D. Blankensteijn,Stefan E Matthiasson,Unnur Thorsteinsdottir,Kari Stefansson +103 more
TL;DR: It was found that rs7025486[A], located within DAB2IP, which encodes an inhibitor of cell growth and survival, is associated with early onset myocardial infarction, but not with intracranial aneurysm or ischemic stroke.