H
Hadi Abderrahim
Researcher at Council on Education for Public Health
Publications - 17
Citations - 5937
Hadi Abderrahim is an academic researcher from Council on Education for Public Health. The author has contributed to research in topics: Yeast artificial chromosome & Immunoglobulin light chain. The author has an hindex of 12, co-authored 17 publications receiving 5855 citations.
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Journal ArticleDOI
Identification and characterization of the familial adenomatous polyposis coli gene
Joanna Groden,Andrew Thliveris,Andrew Thliveris,Wade S. Samowitz,M. Carlson,Lawrence Gelbert,Lawrence Gelbert,Hans Albertsen,Geoff Joslyn,Geoff Joslyn,Jeff Stevens,Jeff Stevens,Lisa Spirio,Margaret Robertson,Margaret Robertson,Leslie Sargeant,Leslie Sargeant,Karen Krapcho,Karen Krapcho,E. Wolff,E. Wolff,Randall W. Burt,John P. Hughes,Janet A. Warrington,John Douglas Mcpherson,John J. Wasmuth,Denis Le Paslier,Hadi Abderrahim,Daniel Cohen,Mark Leppert,Mark Leppert,Ray White,Ray White +32 more
TL;DR: DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes located within a 100 kb region deleted in two of the patients, and data have established that DP2.5 is the APC gene.
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Antigen–specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs
Larry L. Green,M.C. Hardy,Catherine E. Maynard-Currie,H. Tsuda,Donna M. Louie,Michael Mendez,Hadi Abderrahim,Masato Noguchi,Douglas H. Smith,Y. Zeng,N.E. David,H. Sasai,D. Garza,D.G. Brenner,Joanna F. Hales,R.P. McGuinness,Daniel J. Capon,Sue Klapholz,Aya Jakobovits +18 more
TL;DR: This work describes a strategy for producing human monoclonal antibodies in mice by introducing large segments of the human heavy and κ light chain loci contained on yeast artificial chromosomes into the mouse germline, which should provide insight into the adoptive human antibody response and permit the development of fully human monocolonal antibodies with therapeutic potential.
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Identification of deletion mutations and three new genes at the familial polyposis locus
Geoff Joslyn,Geoff Joslyn,M. Carlson,Andrew Thliveris,Andrew Thliveris,Hans Albertsen,Lawrence Gelbert,Lawrence Gelbert,Wade S. Samowitz,Joanna Groden,Jeff Stevens,Jeff Stevens,Lisa Spirio,Margaret Robertson,Margaret Robertson,Leslie Sargeant,Leslie Sargeant,Karen Krapcho,Karen Krapcho,E. Wolff,E. Wolff,Randall W. Burt,John P. Hughes,Janet A. Warrington,John Douglas Mcpherson,John J. Wasmuth,Denis Le Paslier,Hadi Abderrahim,Daniel Cohen,Mark Leppert,Mark Leppert,Ray White,Ray White +32 more
TL;DR: Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC) and two new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle.
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Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
Michael Mendez,Larry L. Green,Corvalan,Xiao-Chi Jia,Catherine E. Maynard-Currie,Xiao-Dong Yang,Michael Gallo,Donna M. Louie,Lee Dv,Erickson Kl,Luna J,Roy Cm,Hadi Abderrahim,Kirschenbaum F,Masato Noguchi,Douglas H. Smith,Atsushi Fukushima,Joanna F. Hales,Sue Klapholz,Mitchell H. Finer,Davis Cg,Krisztina M. Zsebo,Aya Jakobovits +22 more
TL;DR: These results underscore the importance of the large Ig fragments with multiple V genes for restoration of a normal humoral immune response, and suggest that Ig-inactivated mice are likely to be a valuable tool for the generation of therapeutic antibodies.
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Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents.
TL;DR: An inverse relationship between YAC insert size and transformation efficiency is found and indicates that high molecular mass human DNA fragments from partial restriction digests and ligation with the YAC vector in agarose contain the equivalent of approximately seven haploid human genomes.