H
Haiying Qin
Researcher at National Institutes of Health
Publications - 53
Citations - 6955
Haiying Qin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chimeric antigen receptor & T cell. The author has an hindex of 19, co-authored 45 publications receiving 5736 citations. Previous affiliations of Haiying Qin include J. Craig Venter Institute.
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Journal ArticleDOI
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
John F. Heidelberg,Jonathan A. Eisen,William C. Nelson,Rebecca A. Clayton,Michelle L. Gwinn,Robert J. Dodson,Daniel H. Haft,Erin Hickey,Jeremy Peterson,Lowell Umayam,Steven R. Gill,Karen E. Nelson,Timothy D. Read,Hervé Tettelin,Delwood Richardson,Maria D. Ermolaeva,Jessica Vamathevan,Steven Bass,Haiying Qin,Ioana Dragoi,Patrick Sellers,Lisa McDonald,Teresa Utterback,Robert D. Fleishmann,William C. Nierman,Owen White,Steven L. Salzberg,Hamilton O. Smith,Rita R. Colwell,Rita R. Colwell,John J. Mekalanos,J. Craig Venter,Claire M. Fraser +32 more
TL;DR: The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.
Journal ArticleDOI
Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58
Hervé Tettelin,Nigel J. Saunders,John F. Heidelberg,Alex C. Jeffries,Karen E. Nelson,Jonathan A. Eisen,Karen A. Ketchum,Derek W. Hood,John F. Peden,Robert J. Dodson,William C. Nelson,Michelle L. Gwinn,Robert T. DeBoy,Jeremy Peterson,Erin Hickey,Daniel H. Haft,Steven L. Salzberg,Owen White,Robert D. Fleischmann,Brian Dougherty,Tanya Mason,Anne Ciecko,Debbie S. Parksey,Eric Blair,Henry Cittone,Emily B. Clark,Matthew D. Cotton,T. Utterback,Hoda Khouri,Haiying Qin,Jessica Vamathevan,John Gill,Vincenzo Scarlato,Vega Masignani,Mariagrazia Pizza,Guido Grandi,Li Sun,Hamilton O. Smith,Claire M. Fraser,E. Richard Moxon,Rino Rappuoli,J. Craig Venter +41 more
TL;DR: Neisseria meningitidis contains more genes that undergo phase variation than any pathogen studied to date, a mechanism that controls their expression and contributes to the evasion of the host immune system.
Journal ArticleDOI
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.
Terry J. Fry,Nirali N. Shah,Rimas J. Orentas,Maryalice Stetler-Stevenson,Constance M. Yuan,Sneha Ramakrishna,Pamela L. Wolters,Staci Martin,Cindy Delbrook,Bonnie Yates,Haneen Shalabi,Thomas J. Fountaine,Jack F. Shern,Robbie G. Majzner,David F. Stroncek,Marianna Sabatino,Yang Feng,Dimiter S. Dimitrov,Ling Zhang,Sang M. Nguyen,Haiying Qin,Boro Dropulic,Daniel W. Lee,Crystal L. Mackall +23 more
TL;DR: These results are the first to establish the clinical activity of a CD22-CAR in B-all, including leukemia resistant to anti-CD19 immunotherapy, demonstrating potency against B-ALL comparable to that of CD19-CAR at biologically active doses.
Journal ArticleDOI
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1.
Owen White,Jonathan A. Eisen,John F. Heidelberg,Erin Hickey,Jeremy Peterson,Robert J. Dodson,Daniel H. Haft,Michelle L. Gwinn,William C. Nelson,Delwood Richardson,Kelly Moffat,Haiying Qin,Lingxia Jiang,W. Pamphile,M. Crosby,Mian Shen,Jessica Vamathevan,P. Lam,Lisa McDonald,T. Utterback,C. Zalewski,Kira S. Makarova,L. Aravind,Michael J. Daly,Kenneth W. Minton,Robert D. Fleischmann,K. A. Ketchum,Karen E. Nelson,Steven L. Salzberg,Hamilton O. Smith,J C Venter,J C Venter,Claire M. Fraser +32 more
TL;DR: Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.
Journal ArticleDOI
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
Elad Jacoby,Sang M. Nguyen,Thomas J. Fountaine,Kathryn M. Welp,Berkley E. Gryder,Haiying Qin,Yinmeng Yang,Christopher D. Chien,Alix E. Seif,Haiyan Lei,Young K. Song,Javed Khan,Daniel W. Lee,Crystal L. Mackall,Rebecca Gardner,Michael C. Jensen,Jack F. Shern,Terry J. Fry +17 more
TL;DR: Changes in lineage markers including myeloid conversion in patients following CD19 CAR therapy are reported, establishing lineage switch as a mechanism of CAR resistance exposing inherent plasticity in genetic subtypes of pre-B-cell ALL.