Hanan L. Messiha

TL;DR: This bottom‐up modelling study reveals that control over the metabolic network most directly involved in yeast glycolysis is more widely distributed than previously thought.

TL;DR: The photochemistry in CarH that ultimately triggers tetramer dissociation is described; it proceeds via a cob(III)alamin intermediate, which then forms a stable adduct with the protein, which is independent of the radical chemistry common to both coenzyme B12 enzymology and its known photochemistry.

TL;DR: Systems Biology has a mission that puts it at odds with traditional paradigms of physics and molecular biology, such as the simplicity requested by Occam's razor and minimum energy/maximal efficiency, which are shown to be inapt.

TL;DR: The crystal structure of the NADH-dependent bacterial flavoenzyme morphinone reductase has been determined at 2.2-Å resolution in complex with the oxidizing substrate codeinone and it is established that Cys-191 does not act as a crucial acid in the mechanism of reduction of the olefinic bond found in 2-cyclohexenone and codein one.

TL;DR: Overall, the results show a subtle interplay among the effects of Pi, FBP, and pH that results in different regulatory effects on the LDHs of different LABs.