Farid Khan

TL;DR: Prof. Micklefield?s research interests are at the chemistry?biology interface and include the redesign of nucleic acids, small-molecule control of gene expression, biosynthesis and biosynthetic engineering, nonribosomal peptides, biocatalysis, and enzyme mechanism.

TL;DR: DAPA eliminates the need for separate protein expression, purification and spotting, and also overcomes the problem of long-term functional storage of surface-bound proteins.

TL;DR: A double-hexahistidine (His6) tag sequence, comprising two hexahistidines separated by an 11-amino acid spacer, which shows at least 1 order of magnitude stronger binding to Ni-NTA-modified surfaces than a conventional single-His6 tag or two single- his6 tags at N- and C-termini is described.

TL;DR: This bottom‐up modelling study reveals that control over the metabolic network most directly involved in yeast glycolysis is more widely distributed than previously thought.

TL;DR: This approach reveals a complex sequence-fitness mapping, and hypotheses for the physical basis of aptameric binding, and enables rapid design of novel aptamers with desired binding properties, and demonstrates an extension to the approach by incorporating prior knowledge into CLADE, resulting in some of the tightest binding sequences.