Hans Ackerman

TL;DR: A framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations is introduced, and the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection.

TL;DR: The current understanding of the biology of asexual blood-stage parasites and gametocytes and the ability to culture them in vitro lends optimism that high-throughput screenings of large chemical libraries will produce a new generation of antimalarial drugs.

TL;DR: Using an adenoviral reporter assay, the variant which binds p50-p50 results in a reduction of lipopolysaccharide-inducible gene expression in primary human monocytes and illustrates the potential for genetic modulation of inflammatory gene regulation in humans by subtle nucleotide changes that alter the relative binding affinities of different forms of the NF-κB complex.

TL;DR: The IL8-251A allele resides on two haplotypes, only one of which is associated with disease, suggesting that this may not be the functional allele and that selective pressure may have acted on this locus.

TL;DR: This work compares case‐control and transmission/disequilibrium test (TDT) study designs using a well‐established genetic association, the protective effect of the sickle‐cell trait against severe malaria, and proposes a family plus population control study design, which allows both case‐ control and TDT analysis of the cases.