Hans-Peter Lenhof

TL;DR: Application of the two approaches to the proteome analysis of proteins extracted from a tumor tissue revealed that the BU method identified more proteins while STD analysis offered higher sequence coverage, and a high degree of "pseudo-orthogonality" of protein and peptide separation by IP-RPC in both separation dimensions.

TL;DR: It is indicated that miR-34a-5p mimic administered by intravenous administration will likely not only be up-taken by the tumor cells but also by the immune cells, and less immune cells will be attracted to the tumor site.

TL;DR: The Roche Cancer Genome Database (RCGDB), a freely available biological information system integrating different kinds of mutation data, is developed, the first comprehensive integration of disparate cancer genome data like single nucleotide variants, singleucleotide polymorphisms, and chromosomal aberrations.

TL;DR: An approach that allows conformational flexibility for the side—chains while keeping the protein backbone rigid is described, starting from candidates created by a rigid docking algorithm, thus creating reasonable approximations of the true complex structure.

TL;DR: This work demonstrates how real-time ray tracing integrated into a molecular modelling and visualization tool allows for better understanding of the structural arrangement of biomolecules and natural creation of publication-quality images in real- time.