H
Harinder Manku
Researcher at Imperial College London
Publications - 6
Citations - 1091
Harinder Manku is an academic researcher from Imperial College London. The author has contributed to research in topics: Allele & Haplotype. The author has an hindex of 6, co-authored 6 publications receiving 1010 citations. Previous affiliations of Harinder Manku include King's College London & Hammersmith Hospital.
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Journal ArticleDOI
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.
Nicholas Simpson,Paul A. Gatenby,Anastasia Wilson,Shreya Malik,David A. Fulcher,Stuart G. Tangye,Harinder Manku,Timothy J. Vyse,Giovanna Roncador,Gavin A. Huttley,Christopher C. Goodnow,Carola G. Vinuesa,Matthew C. Cook +12 more
TL;DR: These findings in SLE patients are consistent with the autoimmune mechanism in sanroque mice and identify Tfh effector molecules as possible therapeutic targets in a recognizable subset of patients with SLE.
Journal ArticleDOI
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Deborah S. Cunninghame Graham,Robert R. Graham,Harinder Manku,Andrew Wong,John C. Whittaker,Patrick M. Gaffney,Patrick M. Gaffney,Kathy L. Moser,Kathy L. Moser,John D. Rioux,John D. Rioux,David Altshuler,Timothy W. Behrens,Timothy W. Behrens,Timothy J. Vyse +14 more
TL;DR: It is hypothesized that increased expression of TNFSF4 predisposes to SLE either by quantitatively augmenting T cell–APC interaction or by influencing the functional consequences of T cell activation via TNFRSF4.
Journal ArticleDOI
Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation
Deborah S. Cunninghame Graham,Harinder Manku,Susanne Wagner,Julia Reid,Kirsten Timms,Alexander Gutin,Jerry S. Lanchbury,Timothy J. Vyse +7 more
TL;DR: The data support a new mechanism by which an IRF5 polymorphism controls the expression of alternate transcript variants which may have different effects on interferon signalling.
Journal ArticleDOI
Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4
Harinder Manku,Carl D. Langefeld,Sandra G. Guerra,Talat H. Malik,Marta E. Alarcón-Riquelme,Juan-Manuel Anaya,Sang Cheol Bae,Susan A. Boackle,Elizabeth E. Brown,Lindsey A. Criswell,Barry I. Freedman,Patrick M. Gaffney,Peter A. Gregersen,Joel M. Guthridge,Sang Hoon Han,John B. Harley,Chaim O. Jacob,Judith A. James,Judith A. James,Diane L. Kamen,Kenneth M. Kaufman,Jennifer A. Kelly,Javier Martin,Joan T. Merrill,Kathy L. Moser,Timothy B. Niewold,Soyeon Park,Bernardo A. Pons-Estel,Amr H. Sawalha,R. Hal Scofield,R. Hal Scofield,Nan Shen,Anne M. Stevens,Celi Sun,Gary S. Gilkeson,Jeffrey C. Edberg,Robert P. Kimberly,Swapan K. Nath,Betty P. Tsao,Timothy J. Vyse +39 more
TL;DR: In this article, a trans-ancestral approach was used to fine-map the locus of the TNFSF4 causal variants in the autoimmune disease SLE and found strong association of risk alleles in all ethnicities; the AA association replicates in African-American Gullah (152,122).
Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4
Harinder Manku,Carl D. Langefeld,Sandra G. Guerra,Talat H. Malik,Marta E. Alarcón-Riquelme,Juan-Manuel Anaya,Sang Cheol Bae,Susan A. Boackle,Elizabeth E. Brown,Lindsey A. Criswell,Barry I. Freedman,Patrick M. Gaffney,Peter A. Gregersen,Joel M. Guthridge,Sang Hoon Han,John B. Harley,Chaim O. Jacob,Judith A. James,Judith A. James,Diane L. Kamen,Kenneth M. Kaufman,Jennifer A. Kelly,Javier Martin,Joan T. Merrill,Kathy L. Moser,Timothy B. Niewold,Soyeon Park,Bernardo A. Pons-Estel,Amr H. Sawalha,R. Hal Scofield,R. Hal Scofield,Nan Shen,Anne M. Stevens,Celi Sun,Gary S. Gilkeson,Jeffrey C. Edberg,Robert P. Kimberly,Swapan K. Nath,Betty P. Tsao,Timothy J. Vyse +39 more
TL;DR: A global signal at TNFSF4 and a role for the expressed product at multiple stages of lymphocyte dysregulation during SLE pathogenesis is confirmed and the validity of trans-ancestral mapping in a complex trait is confirmed.