D
David A. Fulcher
Researcher at Westmead Hospital
Publications - 59
Citations - 4652
David A. Fulcher is an academic researcher from Westmead Hospital. The author has contributed to research in topics: Interleukin 21 & Antigen. The author has an hindex of 28, co-authored 55 publications receiving 4202 citations. Previous affiliations of David A. Fulcher include Children's Medical Research Institute & University of Sydney.
Papers
More filters
Journal ArticleDOI
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
Cindy S. Ma,Gary Y.J. Chew,Nicholas Simpson,Archana Priyadarshi,Melanie Wong,Bodo Grimbacher,David A. Fulcher,Stuart G. Tangye,Matthew C. Cook,Matthew C. Cook +9 more
TL;DR: A failure of CD4+ T cells harboring heterozygous STAT3 mutations to generate interleukin 17–secreting cells in vivo and in vitro due to a failure to express sufficient levels of the Th17-specific transcriptional regulator retinoid-related orphan receptor γt is demonstrated.
Journal ArticleDOI
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.
Nicholas Simpson,Paul A. Gatenby,Anastasia Wilson,Shreya Malik,David A. Fulcher,Stuart G. Tangye,Harinder Manku,Timothy J. Vyse,Giovanna Roncador,Gavin A. Huttley,Christopher C. Goodnow,Carola G. Vinuesa,Matthew C. Cook +12 more
TL;DR: These findings in SLE patients are consistent with the autoimmune mechanism in sanroque mice and identify Tfh effector molecules as possible therapeutic targets in a recognizable subset of patients with SLE.
Journal ArticleDOI
Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
Suzanne B. Hartley,Michael P. Cooke,David A. Fulcher,Alan W. Harris,Suzanne Cory,Antony Basten,Christopher C. Goodnow +6 more
TL;DR: It is shown that two separate and sequential events, arrested development and cell death, bring about B cell elimination, defining a novel pathway for B cell Elimination, involving an initial stage vulnerable to breakdown in autoimmune disease.
Journal ArticleDOI
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
Danielle T. Avery,Elissa K. Deenick,Elissa K. Deenick,Cindy S. Ma,Cindy S. Ma,Santi Suryani,Santi Suryani,Nicholas Simpson,Gary Y. Chew,Tyani D. Chan,Tyani D. Chan,Umamainthan Palendira,Umamainthan Palendira,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Sharon Choo,Karl Bleasel,Jane Peake,Cecile King,Cecile King,Martyn A. French,Dan Engelhard,Sami Al-Hajjar,Saleh Al-Muhsen,Klaus Magdorf,Joachim Roesler,Peter D. Arkwright,Pravin Hissaria,D. Sean Riminton,Melanie Wong,Robert Brink,Robert Brink,Robert Brink,David A. Fulcher,Jean-Laurent Casanova,Jean-Laurent Casanova,Matthew C. Cook,Stuart G. Tangye,Stuart G. Tangye +39 more
TL;DR: STAT3-activating cytokines such as IL-21 underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients.
Journal ArticleDOI
Functional STAT3 deficiency compromises the generation of human T follicular helper cells
Cindy S. Ma,Cindy S. Ma,Danielle T. Avery,Anna Chan,Marcel Batten,Marcel Batten,Jacinta Bustamante,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Peter D. Arkwright,Alexandra Y. Kreins,Diana Averbuch,Dan Engelhard,Klaus Magdorf,Sara Sebnem Kilic,Yoshiyuki Minegishi,Shigeaki Nonoyama,Martyn A. French,Martyn A. French,Sharon Choo,Joanne Smart,Jane Peake,Melanie Wong,Paul Gray,Matthew C. Cook,Matthew C. Cook,David A. Fulcher,Jean-Laurent Casanova,Jean-Laurent Casanova,Elissa K. Deenick,Elissa K. Deenick,Stuart G. Tangye,Stuart G. Tangye +33 more
TL;DR: CD4(+) T cells from patients deficient in IL-12Rβ1, TYK2, STAT1, and STAT3 are examined to further explore the pathways involved in human Tfh cell differentiation and suggest that defective T fh cell development and/or function contributes to the humoral defects observed in STAT3-deficient patients.