H
Harry Mellor
Researcher at University of Bristol
Publications - 93
Citations - 7993
Harry Mellor is an academic researcher from University of Bristol. The author has contributed to research in topics: GTPase & RHOA. The author has an hindex of 37, co-authored 89 publications receiving 7557 citations. Previous affiliations of Harry Mellor include Lincoln's Inn & Harvard University.
Papers
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Journal ArticleDOI
The extended protein kinase C superfamily.
Harry Mellor,Peter J. Parker +1 more
TL;DR: Studies on simple organisms have shown that PKC signalling paradigms are conserved through evolution from yeast to humans, underscoring the importance of this family in cellular signalling and giving novel insights into PKC function in complex mammalian systems.
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Actin stress fibres.
Stephanie Pellegrin,Harry Mellor +1 more
TL;DR: As the details of stress fibre construction are uncovered, it is becoming clear that different categories of stress fibres exist and some are less suited for cell motility and more suited to static contraction.
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Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides
Jez G. Carlton,Miriam V. Bujny,Brian J. Peter,Viola Oorschot,Anna C. Rutherford,Harry Mellor,Judith Klumperman,Harvey T. McMahon,Peter J. Cullen +8 more
TL;DR: The data support an evolutionarily conserved function for SNX1 from yeast to mammals and provide functional insight into the molecular mechanisms underlying lipid-mediated protein targeting and tubular-based protein sorting.
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The Rho family GTPase Rif induces filopodia through mDia2
Stephanie Pellegrin,Harry Mellor +1 more
TL;DR: The differences between filopodia induced by these two small GTPases are characterized and it is shown that the Rif effector in this pathway is the Diaphanous-related formin mDia2.
Journal ArticleDOI
Imaging Protein Kinase Cα Activation in Cells
Tony Ng,Anthony Squire,Gurdip Hansra,Frédéric Bornancin,Corinne Prevostel,Andrew M. Hanby,William H. Harris,Diana M. Barnes,Sandra Schmidt,Harry Mellor,Philippe I. H. Bastiaens,Peter J. Parker +11 more
TL;DR: Spatially resolved fluorescence resonance energy transfer measured by fluorescence lifetime imaging microscopy (FLIM), provides a method for tracing the catalytic activity of fluorescently tagged proteins inside live cell cultures and enables determination of the functional state of proteins in fixed cells and tissues.