H
Harshil Patel
Researcher at Francis Crick Institute
Publications - 60
Citations - 2379
Harshil Patel is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 17, co-authored 48 publications receiving 1330 citations. Previous affiliations of Harshil Patel include London Research Institute & Oxford Brookes University.
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Journal ArticleDOI
The nf-core framework for community-curated bioinformatics pipelines.
Philip Ewels,Alexander Peltzer,Sven Fillinger,Harshil Patel,Johannes Alneberg,Andreas Wilm,Maxime Garcia,Paolo Di Tommaso,Sven Nahnsen +8 more
TL;DR: The nf-core framework is introduced as a means for the development of collaborative, peerreviewed, best-practice analysis pipelines that can be used across all institutions and research facilities and introduces a higher degree of portability as compared to custom in-house scripts.
Journal ArticleDOI
Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates
TL;DR: The minimum requirements for chromatin replication in vitro are defined and how multiple chromatin factors might modulate replication fork rates in vivo are shown.
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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.
Helena Aegerter,Justina Kulikauskaite,Stefania Crotta,Harshil Patel,Gavin Kelly,Edith M. Hessel,Matthias Mack,Soren Beinke,Andreas Wack +8 more
TL;DR: Following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages that produce increased interleukin-6.
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SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair
Nnennaya Kanu,Eva Grönroos,Pierre Martinez,Rebecca A. Burrell,X. Yi Goh,Jirina Bartkova,Apolinar Maya-Mendoza,Martin Mistrik,Andrew Rowan,Harshil Patel,Adam Rabinowitz,P East,Gareth A. Wilson,Claudio R. Santos,Nicholas McGranahan,Sakshi Gulati,Marco Gerlinger,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Tejal Joshi,Ludmil B. Alexandrov,Michael R. Stratton,Thomas Powles,Nik Matthews,Paul A. Bates,Aengus Stewart,Zoltan Szallasi,Zoltan Szallasi,James Larkin,Jiri Bartek,Charles Swanton +30 more
TL;DR: A role for SETD2 in maintaining genome integrity through nucleosome stabilization, suppression of replication stress and the coordination of DNA repair is suggested.
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The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity
Cristina Morales Torres,Alva Biran,Matthew J. Burney,Harshil Patel,Tristan Henser-Brownhill,Ayelet-Hashahar Shapira Cohen,Yang Li,Rotem Ben-Hamo,Emma Nye,Bradley Spencer-Dene,Probir Chakravarty,Sol Efroni,Nik Matthews,Tom Misteli,Eran Meshorer,Paola Scaffidi,Paola Scaffidi +16 more
TL;DR: It is proposed that only cells insensitive to extracellular differentiation cues, capable of permanently silencing H1.0, can act as self-renewing tumor-maintaining cells and that such a mechanism supports maintenance of several types of cancer.