H
Harumichi Ishigame
Researcher at Yale University
Publications - 29
Citations - 6990
Harumichi Ishigame is an academic researcher from Yale University. The author has contributed to research in topics: Interleukin 17 & Cytotoxic T cell. The author has an hindex of 18, co-authored 29 publications receiving 6224 citations. Previous affiliations of Harumichi Ishigame include University of Tokyo.
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Journal ArticleDOI
IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis
Yutaka Komiyama,Susumu Nakae,Taizo Matsuki,Aya Nambu,Harumichi Ishigame,Shigeru Kakuta,Katsuko Sudo,Yoichiro Iwakura +7 more
TL;DR: The development of experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple sclerosis, was significantly suppressed in IL-17−/− mice; these animals exhibited delayed onset, reduced maximum severity scores, ameliorated histological changes, and early recovery.
Journal ArticleDOI
Functional Specialization of Interleukin-17 Family Members
TL;DR: The identified functions of each IL-17 family member are described and the potential of these molecules as therapeutic targets are discussed.
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The IL-23/IL-17 axis in inflammation
TL;DR: Two studies demonstrate that blocking IL-23 or its downstream factors IL-17 and IL-6, but not the IL-12/IFN-gamma pathways, can significantly suppress disease development in animal models of inflammatory bowel disease and MS.
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Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses
Harumichi Ishigame,Shigeru Kakuta,Takeshi Nagai,Motohiko Kadoki,Aya Nambu,Yutaka Komiyama,Noriyuki Fujikado,Yuko Tanahashi,Aoi Akitsu,Hayato Kotaki,Katsuko Sudo,Susumu Nakae,Chihiro Sasakawa,Yoichiro Iwakura +13 more
TL;DR: It is demonstrated with Il17a(-/-), Il17f(-/-) mice that IL-17F played only marginal roles, if at all, in the development of delayed-type and contact hypersensitivities, autoimmune encephalomyelitis, collagen-induced arthritis, and arthritis in Il1rn(-/-).
Journal ArticleDOI
Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.