Y
Yoshiyuki Adachi
Researcher at Tokyo University of Pharmacy and Life Sciences
Publications - 234
Citations - 8314
Yoshiyuki Adachi is an academic researcher from Tokyo University of Pharmacy and Life Sciences. The author has contributed to research in topics: Glucan & Cytokine. The author has an hindex of 43, co-authored 228 publications receiving 7788 citations. Previous affiliations of Yoshiyuki Adachi include University of Tokyo.
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Journal ArticleDOI
Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.
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Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.
Shinobu Saijo,Noriyuki Fujikado,Takahisa Furuta,Soo Hyun Chung,Hayato Kotaki,Keisuke Seki,Katsuko Sudo,Shizuo Akira,Yoshiyuki Adachi,Naohito Ohno,Takeshi Kinjo,Kiwamu Nakamura,Kazuyoshi Kawakami,Yoichiro Iwakura +13 more
TL;DR: Protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species, and wild-type and dectIn-1-knockout mice were equally susceptible to candidA infection.
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Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14
Sachiko Akashi,Shin-ichiroh Saitoh,Yasutaka Wakabayashi,Takane Kikuchi,Noriaki Takamura,Yoshinori Nagai,Yutaka Kusumoto,Koichi Fukase,Shoichi Kusumoto,Yoshiyuki Adachi,Atsushi Kosugi,Kensuke Miyake +11 more
TL;DR: Direct LPS interaction with cell surface TLR4-MD-2 that is distinct from that with MD-2 or CD14 is revealed, suggesting a role for CD14 in LPS loading onto TLR2 but not in the interaction itself between LPS and TLR3-MD2.
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Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells.
Isao Nagaoka,Satoko Hirota,François Niyonsaba,Michimasa Hirata,Yoshiyuki Adachi,Hiroshi Tamura,Didier Heumann +6 more
TL;DR: Cathelicidin peptides human CAP18 and guinea pig CAP11 probably exert protective actions against endotoxin shock by blocking the binding of LPS to CD14+ cells, thereby suppressing the production of cytokines by these cells via their potent binding activities for LPS and CD14.
Journal ArticleDOI
Characterization of β-Glucan Recognition Site on C-Type Lectin, Dectin 1
Yoshiyuki Adachi,Takashi Ishii,Yoshihiko Ikeda,Akiyoshi Hoshino,Hiroshi Tamura,Jun Aketagawa,Shigenori Tanaka,Naohito Ohno +7 more
TL;DR: The results suggest that the amino acid sequence W221-I222-H223 is critical for formation of a β-glucan binding site in the CRD of dectin 1.