N
Natsuo Yamamoto
Researcher at Fukushima Medical University
Publications - 36
Citations - 1725
Natsuo Yamamoto is an academic researcher from Fukushima Medical University. The author has contributed to research in topics: Cytokine & Natural killer T cell. The author has an hindex of 17, co-authored 36 publications receiving 1585 citations. Previous affiliations of Natsuo Yamamoto include Tohoku University & University of the Ryukyus.
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Journal ArticleDOI
Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.
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Critical role of Vα14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection
Kazuyoshi Kawakami,Natsuo Yamamoto,Yuki Kinjo,Kazuya Miyagi,Chikara Nakasone,Kaori Uezu,Takeshi Kinjo,Toshinori Nakayama,Masaru Taniguchi,Atsushi Saito +9 more
TL;DR: MCP‐1‐dependent recruitment of Vα14+ NKT cells and their critical role in early host protection against S. pneumoniae by promoting the trafficking of neutrophils to the site of infection are demonstrated.
Journal ArticleDOI
Toll-Like Receptor 9-Dependent Activation of Myeloid Dendritic Cells by Deoxynucleic Acids from Candida albicans
Akiko Miyazato,Akiko Miyazato,Kiwamu Nakamura,Natsuo Yamamoto,Héctor M. Mora-Montes,Misuzu Tanaka,Yuzuru Abe,Daiki Tanno,Ken Inden,Xiao Gang,Keiko Ishii,Kiyoshi Takeda,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Yoshiyuki Adachi,Naohito Ohno,Kotaro Mitsutake,Neil A. R. Gow,Mitsuo Kaku,Kazuyoshi Kawakami +20 more
TL;DR: Results suggested that C. albicans DNA activated BM-DCs through a TLR9-mediated signaling pathway using a mechanism independent of the unmethylated CpG motif, which suggested that the innate immune system of humans recognizes the human pathogenic fungus CandidaAlbicans via sugar polymers present in the cell wall.
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Role of interferon-γ in Vα14+ natural killer T cell-mediated host defense against Streptococcus pneumoniae infection in murine lungs
Masashi Nakamatsu,Natsuo Yamamoto,Masumitsu Hatta,Chikara Nakasone,Takeshi Kinjo,Kazuya Miyagi,Kaori Uezu,Kiwamu Nakamura,Kiwamu Nakamura,Toshinori Nakayama,Masaru Taniguchi,Yoichiro Iwakura,Mitsuo Kaku,Jiro Fujita,Kazuyoshi Kawakami,Kazuyoshi Kawakami +15 more
TL;DR: The results demonstrated that IFN-γ plays an important role in the neutrophil-mediated host protective responses against pneumococcal infection promoted by Vα14+ NKT cells.
Journal ArticleDOI
Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection.
Chikara Nakasone,Natsuo Yamamoto,Masashi Nakamatsu,Takeshi Kinjo,Kazuya Miyagi,Kaori Uezu,Kiwamu Nakamura,Kiwamu Nakamura,Futoshi Higa,Hiromichi Ishikawa,Rebecca L. O'Brien,Koichi Ikuta,Mitsuo Kaku,Jiro Fujita,Kazuyoshi Kawakami,Kazuyoshi Kawakami +15 more
TL;DR: It is demonstrated that Vgamma4(+) gammadelta T cells play an important role in the neutrophil-mediated host defense against S. pneumoniae infection by promoting the synthesis of TNF-alpha and possibly of MIP-2 in the lungs.