S
Soo Hyun Chung
Researcher at Tokyo University of Science
Publications - 10
Citations - 1404
Soo Hyun Chung is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: T cell & Cytokine. The author has an hindex of 5, co-authored 7 publications receiving 1275 citations. Previous affiliations of Soo Hyun Chung include University of Tokyo.
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Journal ArticleDOI
Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.
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Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.
Shinobu Saijo,Noriyuki Fujikado,Takahisa Furuta,Soo Hyun Chung,Hayato Kotaki,Keisuke Seki,Katsuko Sudo,Shizuo Akira,Yoshiyuki Adachi,Naohito Ohno,Takeshi Kinjo,Kiwamu Nakamura,Kazuyoshi Kawakami,Yoichiro Iwakura +13 more
TL;DR: Protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species, and wild-type and dectIn-1-knockout mice were equally susceptible to candidA infection.
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IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2 + Vγ6 + γδ T cells
Aoi Akitsu,Harumichi Ishigame,Shigeru Kakuta,Soo Hyun Chung,Satoshi Ikeda,Kenji Shimizu,Sachiko Kubo,Yang Liu,Masayuki Umemura,Goro Matsuzaki,Yasunobu Yoshikai,Shinobu Saijo,Yoichiro Iwakura +12 more
TL;DR: This work shows that both CD4+ and γδ17 cells are required for the development of autoimmune arthritis in IL-1 receptor antagonist (IL-1Ra)-deficient mice, and demonstrates a pathogenic mechanism in which adaptive and innate immunity induce an autoimmune disease in a coordinated manner.
Journal ArticleDOI
DCIR Maintains Bone Homeostasis by Regulating IFN-γ Production in T Cells
Takumi Maruhashi,Tomonori Kaifu,Rikio Yabe,Akimasa Seno,Soo Hyun Chung,Noriyuki Fujikado,Yoichiro Iwakura +6 more
TL;DR: IFN-γ is a positive chondrogenic and osteoblastogenic factor, and DCIR is a crucial regulator of bone metabolism; consequently, both factors are potential targets for therapies directed against bone metabolic diseases.
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IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Yuriko Hashiguchi,Rikio Yabe,Rikio Yabe,Soo Hyun Chung,Masanori A. Murayama,Kaori Yoshida,Kenzo Matsuo,Sachiko Kubo,Shinobu Saijo,Yuumi Nakamura,Hiroyuki Matsue,Yoichiro Iwakura +11 more
TL;DR: It is suggested that TLR/CLR signaling–induced IL-36α plays an important role for the development of psoriasiform dermatitis by enhancing Th17-related cytokine/chemokine production in skin-resident cells via a local autoamplification loop.