H
Hassen Kared
Researcher at Agency for Science, Technology and Research
Publications - 21
Citations - 1765
Hassen Kared is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 12, co-authored 15 publications receiving 954 citations. Previous affiliations of Hassen Kared include Singapore Immunology Network.
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Journal ArticleDOI
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Yannick Simoni,Etienne Becht,Michael G. Fehlings,Chiew Yee Loh,Si-Lin Koo,Karen Wei Weng Teng,Joe Poh Sheng Yeong,Joe Poh Sheng Yeong,Rahul Nahar,Tong Zhang,Hassen Kared,Kaibo Duan,Nicholas Ang,Michael Poidinger,Yin Yeng Lee,Anis Larbi,Alexis Jiaying Khng,Emile Tan,Cherylin Fu,Ronnie Mathew,Melissa Ching Ching Teo,Wan-Teck Lim,Chee Keong Toh,Boon-Hean Ong,Tina Koh,Axel M. Hillmer,Angela Takano,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Eng Huat Tan,Weiwei Zhai,Daniel Shao-Weng Tan,Daniel Shao-Weng Tan,Iain Beehuat Tan,Iain Beehuat Tan,Iain Beehuat Tan,Evan W. Newell +37 more
TL;DR: It is shown that human lung and colorectal cancer CD8+ TILs can not only be specific for tumour antigens, but also recognize a wide range of epitopes unrelated to cancer (such as those from Epstein–Barr virus, human cytomegalovirus or influenza virus).
Journal ArticleDOI
SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.
Hassen Kared,Andrew D. Redd,Evan M. Bloch,Tania S. Bonny,Hermi Sumatoh,Faris Kairi,Daniel Carbajo,Brian Abel,Evan W. Newell,Maria Bettinotti,Sarah E. Benner,Eshan U. Patel,Kirsten Littlefield,Oliver Laeyendecker,Shmuel Shoham,David J. Sullivan,Arturo Casadevall,Andrew Pekosz,Alessandra Nardin,Michael G. Fehlings,Aaron A.R. Tobian,Thomas C. Quinn +21 more
TL;DR: Modelling demonstrated a coordinated and dynamic immune response characterized by a decrease in inflammation, increase in neutralizing antibody titer, and differentiation of a specific CD8+ T cell response.
Journal ArticleDOI
CD57 in human natural killer cells and T-lymphocytes.
Hassen Kared,Serena Martelli,Serena Martelli,Tze Pin Ng,Sylvia L.F. Pender,Anis Larbi,Anis Larbi,Anis Larbi +7 more
TL;DR: Current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease is reviewed and how this marker can inform researchers about their likely functions in human blood and tissues in vivo is discussed.
Journal ArticleDOI
Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies.
Yanxia Lu,Crystal Tze Ying Tan,Ma Shwe Zin Nyunt,Esther Wing Hei Mok,Xavier Camous,Hassen Kared,Tamas Fulop,Liang Feng,Tze Pin Ng,Anis Larbi,Anis Larbi +10 more
TL;DR: An association between inflammation, cellular immunity, and the process of frailty is supported, which has significance for the early identification ofFrailty using circulating biomarkers prior to clinical manifestations of severe functional decline in the elderly.
Journal ArticleDOI
Minimal Crossover between Mutations Associated with Omicron Variant of SARS-CoV-2 and CD8+ T-Cell Epitopes Identified in COVID-19 Convalescent Individuals
Andrew D. Redd,Alessandra Nardin,Hassen Kared,Evan M. Bloch,Brian Abel,Andrew Pekosz,Oliver Laeyendecker,Michael G. Fehlings,Thomas C. Quinn,Aaron A.R. Tobian +9 more
TL;DR: It is suggested that virtually all individuals with existing anti-SARS- CoV-2 CD8+ T-cell responses should recognize the Omicron VOC and that SARS-CoV- 2 has not evolved extensive T- cell escape mutations at this time.