Heidi Contreras

TL;DR: It is shown that this nonpathogenic bacterium can outcompete and reduce S. Typhimurium colonization in mouse models of acute colitis and chronic persistent infection by administering Escherichia coli strain Nissle 1917, which assimilates iron by similar mechanisms.

TL;DR: This review presents recent structural and biochemical data that provide mechanistic insights into several bacterial heme uptake pathways, encompassing the sequestration of heme from human hemoproteins to secreted or membrane-associated bacterial proteins, the transport ofHeme across bacterial membranes, and the degradation of he me within the bacterial cytosol to liberate iron.

TL;DR: This study characterized each Rel protein pair and established that they are functional TA modules, and determined that all six rel genes are expressed in broth-grown M. tuberculosis, whereas relE, relF, and relK are expressed during infection of human macrophages.

TL;DR: It is shown by co-purification and electron microscopy that mycobacteria via Mt-Enc can encapsulate Mt-DyP, Mt-BfrB, and Mt-FolB, which may aid in detoxification of the local environment to ensure long term survival.

TL;DR: MmpL3 and MmpL11 are potential heme transporters, whereby heme is transported into the cytosol, as elucidates a key step in the mycobacterial uptake of heme, and it may be useful in the development of anti-tuberculosis drugs targeting this pathway.