H
Helen L. Yin
Researcher at University of Texas Southwestern Medical Center
Publications - 122
Citations - 14414
Helen L. Yin is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Gelsolin & Actin. The author has an hindex of 64, co-authored 121 publications receiving 13899 citations. Previous affiliations of Helen L. Yin include University of Texas at Austin & Harvard University.
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Journal ArticleDOI
Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein
Helen L. Yin,Thomas P. Stossel +1 more
TL;DR: The authors have isolated a calcium-dependent regulatory protein from macrophages and call it gelsolin, providing a possible link to abundant indirect evidence implicating calcium in the regulation of locomotion, secretion and endocytosis.
Journal ArticleDOI
Phosphoinositide regulation of the actin cytoskeleton.
Helen L. Yin,Paul A. Janmey +1 more
TL;DR: This review presents tantalizing evidence that suggests how binding of selected cytoskeletal proteins to membrane PPIs may promote PPI clustering into raft lipid microdomains, alter their accessibility to other proteins, and even distort the bilayer conformation.
Journal ArticleDOI
Gelsolin, a Multifunctional Actin Regulatory Protein
TL;DR: Data supporting the role of gelsolin in cytoskeletal remodeling and phosphoinositide signaling is summarized and the structural basis for the Ca and PIP2 regulation of severing and capping by gelsolini is discussed.
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Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi
Ying-Jie Wang,Jing Wang,Hui Qiao Sun,Manuel Martinez,Yu Xiao Sun,Eric Macia,Tomas Kirchhausen,Joseph P. Albanesi,Michael G. Roth,Helen L. Yin +9 more
TL;DR: It is proposed that PI4KIIalpha establishes the Golgi's unique lipid-defined organelle identity by generating PI(4)P-rich domains that specify the docking of the AP-1 coat machinery.
Journal ArticleDOI
Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
Andrew L. Rozelle,Laura M. Machesky,Masaya Yamamoto,Mariëtte H.E. Driessens,Robert H. Insall,Michael G. Roth,Katherine Luby-Phelps,Gerard Marriott,Alan Hall,Helen L. Yin +9 more
TL;DR: Overexpression of type I phosphatidylinositol phosphate 5-kinase (PIP5KI), which synthesizes PIP(2), promoted actin polymerization from membrane-bound vesicles to form motile actin comets, establishing that rafts promote comet formation.