M
Manuel Martinez
Researcher at University of Texas Southwestern Medical Center
Publications - 6
Citations - 1029
Manuel Martinez is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Phosphatidylinositol & Kinase. The author has an hindex of 5, co-authored 6 publications receiving 978 citations.
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Journal ArticleDOI
Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi
Ying-Jie Wang,Jing Wang,Hui Qiao Sun,Manuel Martinez,Yu Xiao Sun,Eric Macia,Tomas Kirchhausen,Joseph P. Albanesi,Michael G. Roth,Helen L. Yin +9 more
TL;DR: It is proposed that PI4KIIalpha establishes the Golgi's unique lipid-defined organelle identity by generating PI(4)P-rich domains that specify the docking of the AP-1 coat machinery.
Journal ArticleDOI
New caged coumarin fluorophores with extraordinary uncaging cross sections suitable for biological imaging applications.
TL;DR: A new class of caged coumarin fluorophores is designed and synthesized, which displayed more than 200-fold fluorescence enhancement after UV photolysis and the mechanistic study, together with the two-photon uncaging data, suggested that the cou marin moiety serves as an antenna to enhance the light harvesting efficiency of the coumarins cage.
Journal ArticleDOI
Type II Phosphatidylinositol 4-Kinase β Is a Cytosolic and Peripheral Membrane Protein That Is Recruited to the Plasma Membrane and Activated by Rac-GTP
Yongjie Wei,Hui Qiao Sun,Masaya Yamamoto,Paweł Włodarski,Kaiko Kunii,Manuel Martinez,Barbara Barylko,Joseph P. Albanesi,Helen L. Yin +8 more
TL;DR: It is concluded that PI4KIIα and PI4kIIβ may have partially overlapping, but not identical, functions in how phosphoinositide cascades are propagated in cells.
Journal ArticleDOI
Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin. Role of human fucosyltransferase-IV and -VII. Vol. 280 (2005) 5378–5390
Manuel Martinez,Magali Joffraud,Sylvain Giraud,Bénédicte Baïsse,Michael Pierre Bernimoulin,Marc Schapira,Olivier Spertini +6 more
TL;DR: It is confirmed that core-2 O-glycans attached to Thr-57 play a critical role in supporting L- and P-selectin-dependent rolling on PSGL-1 and revealed that additional binding sites support >75% of E- selectin-mediated rolling.
Journal ArticleDOI
Hypertonic Stress Increases Phosphatidylinositol 4,5-Bisphosphate Levels by Activating PIP5KIβ
Masaya Yamamoto,Mark Z. Chen,Ying-Jie Wang,Hui Qiao Sun,Yongjie Wei,Manuel Martinez,Helen L. Yin +6 more
TL;DR: The results establish a cause-and-effect relation between PIP5KIβ dephosphorylation, lipid kinase activation, and PIP2 increase in cells, which can orchestrate multiple downstream responses, including the reorganization of the actin cytoskeleton.