Gerald T. Nepom

TL;DR: Molecular and genetic studies of HLA class-II genes provide new insights into the basis for MHC associations with autoimmunity and suggest a number of possible mechanisms critical for autoimmune triggering events involving class- II molecules.

TL;DR: It is demonstrated that disease-associated autoreactive T cells from patients with type-1 diabetes mellitus or rheumatoid arthritis are mainly CD4+CCR7−CD45RA− effector memory T cells (TEM cells) with elevated Kv1.3 potassium channel expression, which ameliorate pristane-induced arthritis in rats and reduce the incidence of experimental autoimmune diabetes in diabetes-prone rats.

TL;DR: Recent advances in knowledge of the genetics of type 1 diabetes are reviewed and it is shown how this information could find clinical applications of considerable consequence.

TL;DR: The authors found association between narcolepsy and polymorphisms in the TRA@ (T-cell receptor alpha) locus, with highest significance at rs1154155 (average allelic odds ratio 1.69, genotypic odds ratios 1.94 and 2.55, P < 10(-21), 1,830 cases, 2,164 controls).

TL;DR: Soluble tetramerized class II MHC molecules, loaded with an immunodominant peptide from hemagglutinin (HA) and labeled with fluorescent dyes, were constructed and used to directly identify antigen-specific T cells from influenza-immune individuals.