H
Hermann Josef Gertz
Researcher at Leipzig University
Publications - 16
Citations - 656
Hermann Josef Gertz is an academic researcher from Leipzig University. The author has contributed to research in topics: Dementia & Neuropsychology. The author has an hindex of 9, co-authored 16 publications receiving 576 citations.
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Journal ArticleDOI
Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.
Teodoro Del Ser,Klaus C. Steinwachs,Hermann Josef Gertz,María V. Andrés,Belén Gómez-Carrillo,Miguel Medina,Joan A. Vericat,Pilar Redondo,David Fleet,Teresa Leon +9 more
TL;DR: This small pilot study provides valuable safety and efficacy estimates for the treatment of AD patients with tideglusib, currently being confirmed in a larger clinical trial.
Journal ArticleDOI
Reduced α4β2*–Nicotinic Acetylcholine Receptor Binding and Its Relationship to Mild Cognitive and Depressive Symptoms in Parkinson Disease
Philipp Meyer,Karl Strecker,Kai Kendziorra,Georg Becker,Swen Hesse,Dominique Woelpl,Anke Hensel,Marianne Patt,Dietlind Sorger,Florian Wegner,Donald Lobsien,Henryk Barthel,Peter Brust,Hermann Josef Gertz,Osama Sabri,Johannes Schwarz +15 more
TL;DR: There is a broad reduction of alpha4beta2*-nAChR availability in patients with PD without clinically manifest dementia or depression compared with healthy volunteers, and novel in vivo evidence for a role of the cholinergic neurotransmission in psychiatric comorbidity of PD is provided.
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Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia.
Lutz Frölich,Oliver Peters,Piotr Lewczuk,Piotr Lewczuk,Oliver Gruber,Stefan J. Teipel,Stefan J. Teipel,Hermann Josef Gertz,Holger Jahn,Frank Jessen,Frank Jessen,Frank Jessen,Alexander Kurz,Christian Luckhaus,Michael Hüll,Johannes Pantel,Friedel M. Reischies,Johannes Schröder,Michael Wagner,Otto Rienhoff,Stefanie Wolf,Christopher F. Bauer,Johannes Schuchhardt,Isabella Heuser,Eckart Rüther,Fritz A. Henn,Wolfgang Maier,Jens Wiltfang,Johannes Kornhuber,Johannes Kornhuber +29 more
TL;DR: A combination of two biomarkers of neurodegeneration is not superior over the single parameters in identifying patients with MCI who are most likely to progress to AD dementia, although there is a gradual increase in the statistical measures across increasing biomarker combinations.
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The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey
Martina Bocchetta,Samantha Galluzzi,Patrick G. Kehoe,Eduardo Aguera,Roberto Bernabei,Roger Bullock,Mathieu Ceccaldi,Jean-François Dartigues,Alexandre de Mendonça,Mira Didic,Maria Eriksdotter,Olivier Felician,Lutz Frölich,Hermann Josef Gertz,Merja Hallikainen,Steen G. Hasselbalch,Lucrezia Hausner,Isabell Heuser,Frank Jessen,Roy W. Jones,Alexander Kurz,Brian A. Lawlor,Alberto Lleó,Pablo Martinez-Lage,Patrizia Mecocci,Shima Mehrabian,Andreas U. Monsch,Flavio Nobili,Agneta Nordberg,Marcel G. M. Olde Rikkert,Jean Marc Orgogozo,Florence Pasquier,Oliver Peters,Eric Salmon,Carmen Sánchez-Castellano,Isabel Santana,Marie Sarazin,Latchezar Traykov,Magda Tsolaki,Pieter Jelle Visser,Pieter Jelle Visser,Åsa K. Wallin,Gordon K. Wilcock,David Wilkinson,Henrike Wolf,Görsev Yener,Dina Zekry,Giovanni B. Frisoni +47 more
TL;DR: Responses largely agreed that a combination of amyloidosis and neuronal injury biomarkers was a strongly indicative AD signature, and felt “very/extremely” comfortable delivering a diagnosis of MCI due to AD.
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Texture-based segmentation of diffuse lesions of the brain's white matter.
TL;DR: In this article, a segmentation based on texture properties is proposed to segment diffuse lesions of the white matter of the human brain in magnetic resonance images of elderly subjects, which are typically caused by small vessel diseases (e.g., due to hypertension, diabetes, and related to cognitive decline).