H
Hiroki R. Ueda
Researcher at University of Tokyo
Publications - 247
Citations - 21711
Hiroki R. Ueda is an academic researcher from University of Tokyo. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 59, co-authored 211 publications receiving 18300 citations. Previous affiliations of Hiroki R. Ueda include Intec, Inc. & Osaka University.
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Journal ArticleDOI
Advanced CUBIC tissue clearing for whole-organ cell profiling.
Katsuhiko Matsumoto,Tomoki T Mitani,Shuhei A. Horiguchi,Junichi Kaneshiro,Tatsuya C. Murakami,Tomoyuki Mano,Hiroshi Fujishima,Ayumu Konno,Tomonobu M. Watanabe,Hirokazu Hirai,Hiroki R. Ueda +10 more
TL;DR: This protocol enables preparation of high-transparency organs that retain fluorescent protein signals within 7–21 d by immersion in CUBIC reagents, and allows analysis of numerous samples, providing a platform for next-generation biomedical research.
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Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles
Hiroki R. Ueda,Wenbin Chen,Yoichi Minami,Sato Honma,Ken-ichi Honma,Masamitsu Iino,Seiichi Hashimoto +6 more
TL;DR: The results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine.
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CUBIC pathology: three-dimensional imaging for pathological diagnosis
Satoshi Nojima,Etsuo A. Susaki,Etsuo A. Susaki,Etsuo A. Susaki,Kyotaro Yoshida,Hiroyoshi Takemoto,Naoto Tsujimura,Shohei Iijima,Ko Takachi,Yujiro Nakahara,Shinichiro Tahara,Kenji Ohshima,Masako Kurashige,Yumiko Hori,Naoki Wada,Jun-ichiro Ikeda,Atsushi Kumanogoh,Eiichi Morii,Hiroki R. Ueda,Hiroki R. Ueda +19 more
TL;DR: The results indicate that CUBIC significantly contributes to retrospective and prospective clinicopathological diagnosis, which might lead to the establishment of a novel field of medical science based on 3D histopathology.
Journal ArticleDOI
The BMAL1 C terminus regulates the circadian transcription feedback loop
Yota B. Kiyohara,Sayaka Tagao,Filippo Tamanini,Akira Morita,Yukiko Sugisawa,Maya Yasuda,Iori Yamanaka,Hiroki R. Ueda,Gijsbertus T. J. van der Horst,Takao Kondo,Kazuhiro Yagita +10 more
TL;DR: A molecular genetic screening assay for mutant circadian clock proteins that is based on real-time circadian rhythm monitoring in cultured fibroblasts suggests that the C-terminal region of BMAL1 is involved in determining the balance between circadian transcriptional activation and suppression.
Journal ArticleDOI
Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene.
Genshiro A. Sunagawa,Kenta Sumiyama,Maki Ukai-Tadenuma,Dimitri Perrin,Dimitri Perrin,Hiroshi Fujishima,Hideki Ukai,Osamu Nishimura,Shoi Shi,Rei-ichiro Ohno,Ryohei Narumi,Yoshihiro Shimizu,Daisuke Tone,Koji L. Ode,Shigehiro Kuraku,Hiroki R. Ueda,Hiroki R. Ueda +16 more
TL;DR: It is shown that the triple targeting of a single gene using the CRISPR/Cas9 system achieves almost perfect KO efficiency, and a respiration-based fully automated non-invasive sleep phenotyping system, the Snappy Sleep Stager (SSS), is developed, for high-performance sleep/wake staging.