H
Hiroki R. Ueda
Researcher at University of Tokyo
Publications - 247
Citations - 21711
Hiroki R. Ueda is an academic researcher from University of Tokyo. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 59, co-authored 211 publications receiving 18300 citations. Previous affiliations of Hiroki R. Ueda include Intec, Inc. & Osaka University.
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Journal ArticleDOI
Tissue clearing and its applications in neuroscience
Hiroki R. Ueda,Ali Ertürk,Kwanghun Chung,Viviana Gradinaru,Alain Chédotal,Pavel Tomancak,Pavel Tomancak,Philipp J. Keller +7 more
TL;DR: How tissue-clearing methods could provide an unbiased, system-level view of mammalian bodies and human specimens is discussed and future opportunities for the use of these methods in human neuroscience are discussed.
Journal Article
Whole-Body Imaging with Single-Cell Resolution by Tissue Decolorization
Kazuki Tainaka,Shimpei I. Kubota,Takeru Q. Suyama,Etsuo A. Susaki,Dimitri Perrin,Maki Ukai-Tadenuma,Hideki Ukai,Hiroki R. Ueda +7 more
TL;DR: It is shown that an aminoalcohol decolorizes blood by efficiently eluting the heme chromophore from hemoglobin, suggesting that whole-body imaging of colorless tissues at high resolution will contribute to organism-level systems biology.
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Genome-wide transcriptional orchestration of circadian rhythms in Drosophila
Hiroki R. Ueda,Akira Matsumoto,Miho Kawamura,Masamitsu Iino,Teiichi Tanimura,Seiichi Hashimoto +5 more
TL;DR: This work used a high density oligonucleotide probe array to profile gene expression patterns in Drosophila under light-dark and constant dark conditions and found that many genes involved in diverse functions are under circadian control and reveal the complexity of circadian gene expression in Dosophila.
Journal ArticleDOI
Delay in Feedback Repression by Cryptochrome 1 Is Required for Circadian Clock Function
Maki Ukai-Tadenuma,Rikuhiro G. Yamada,Haiyan Xu,Jürgen A. Ripperger,Andrew C. Liu,Hiroki R. Ueda +5 more
TL;DR: It is revealed that a combination of day-time elements within the Cry1-proximal promoter and night- time elements within its intronic enhancer gives rise to evening-time expression and phase delay in Cry1 transcription is required for mammalian clock function.
Journal ArticleDOI
Measurement of internal body time by blood metabolomics
Yoichi Minami,Takeya Kasukawa,Yuji Kakazu,Masayuki Iigo,Masahiro Sugimoto,Masahiro Sugimoto,Satsuki Ikeda,Akira Yasui,Gijsbertus T. J. van der Horst,Tomoyoshi Soga,Hiroki R. Ueda +10 more
TL;DR: The results suggest the potential for metabolomics-based detection of BT (“metabolite-timetable method”), which will lead to the realization of chronotherapy and personalized medicine.