H
Hiroki R. Ueda
Researcher at University of Tokyo
Publications - 247
Citations - 21711
Hiroki R. Ueda is an academic researcher from University of Tokyo. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 59, co-authored 211 publications receiving 18300 citations. Previous affiliations of Hiroki R. Ueda include Intec, Inc. & Osaka University.
Papers
More filters
Journal ArticleDOI
FASTER: an unsupervised fully-automated sleep staging method for mice
TL;DR: FASTER can accurately identify sleep patterns in mice that have been perturbed by drugs or by genetic modification of a clock gene and the overall accuracy is over 90% in every group.
Journal ArticleDOI
Visualization and molecular characterization of whole-brain vascular networks with capillary resolution.
Takeyuki Miyawaki,Shota Morikawa,Etsuo A. Susaki,Ai Nakashima,Haruki Takeuchi,Shun Yamaguchi,Hiroki R. Ueda,Yuji Ikegaya,Yuji Ikegaya +8 more
TL;DR: SeeNet is a method for near-complete three-dimensional visualization of cerebral vascular networks with high signal-to-noise ratios compatible with molecular phenotyping and reveals a hitherto unidentified vascular pathway bridging cerebral and hippocampal vessels, serving as a potential tool to evaluate the connectivity of cerebral vasculature.
Journal ArticleDOI
Genetic and epigenetic stability of oligodendrogliomas at recurrence
Koki Aihara,Akitake Mukasa,Genta Nagae,Masashi Nomura,Shogo Yamamoto,Hiroki R. Ueda,Kenji Tatsuno,Junji Shibahara,Miwako Takahashi,Toshimitsu Momose,Shota Tanaka,Shunsaku Takayanagi,Shunsuke Yanagisawa,Takahide Nejo,Satoshi Takahashi,Mayu Omata,Ryohei Otani,Kuniaki Saito,Yoshitaka Narita,Motoo Nagane,Ryo Nishikawa,Keisuke Ueki,Hiroyuki Aburatani,Nobuhito Saito +23 more
TL;DR: Although oligodendroglioma displays marked mutational heterogeneity, histological malignant transformation accompanying events such as considerable increase in mutation number and epigenetic profile change were not observed at recurrence, indicating that noticeable temporal and spatial genetic heterogeneity in oligodendedrogliomas does not result in rapid tumor progression.
Journal ArticleDOI
Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy.
Tomoyuki Mano,Alexandre Albanese,Hans-Ulrich Dodt,Hans-Ulrich Dodt,Ali Ertürk,Viviana Gradinaru,Jennifer B. Treweek,Jennifer B. Treweek,Atsushi Miyawaki,Kwanghun Chung,Hiroki R. Ueda +10 more
TL;DR: In this photo essay, a sampling of technologies from laboratories at the forefront of whole-brain clearing and imaging for high-resolution analysis of cell populations and neuronal circuits are presented.
Journal ArticleDOI
Distinct molecular profile of diffuse cerebellar gliomas.
Masashi Nomura,Akitake Mukasa,Genta Nagae,Shogo Yamamoto,Kenji Tatsuno,Hiroki R. Ueda,Shiro Fukuda,Takayoshi Umeda,Tomonari Suzuki,Ryohei Otani,Keiichi Kobayashi,Takashi Maruyama,Shota Tanaka,Shunsaku Takayanagi,Takahide Nejo,Satoshi Takahashi,Koichi Ichimura,Taishi Nakamura,Yoshihiro Muragaki,Yoshitaka Narita,Motoo Nagane,Keisuke Ueki,Ryo Nishikawa,Junji Shibahara,Hiroyuki Aburatani,Nobuhito Saito +25 more
TL;DR: DNA methylation profile analysis demonstrated that all DCGs except for those with H3F3A mutations were categorized in the “RTK I (PDGFRA)” group, and those DCGs had a gene expression signature that was highly associated with PDGFRA, and promoter methylation of transcription factors genes associated with glial development showed a characteristic pattern presumably reflecting their tumor origin.