Hiroki R. Ueda

TL;DR: A strategy for developing hydrophilic chemical cocktails for tissue delipidation, decoloring, refractive index (RI) matching, and decalcification, based on comprehensive chemical profiling is described.

TL;DR: This work constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency and accurately determined internal body time within 3 h from just two anti-phase blood samples, enabling highly optimized and personalized medicine.

TL;DR: This review uses the mammalian circadian clock as a model system and describes the application of systems-biological approaches to fundamental problems in this model, which has allowed the identification of transcriptional/posttranscriptional circuits, the discovery of a temperature-insensitive period-determining process, and theiscovery of desynchronization of individual clock cells underlying the singularity behavior of mammalian clocks.

TL;DR: CUBIC-cancer analysis suggests that the epithelial-mesenchymal transition promotes not only extravasation but also cell survival at metastatic sites, and suggests that a scalable analytical pipeline with these three modalities may contribute to addressing currently incurable metastatic diseases.

TL;DR: It is proposed that the competition between cyclic CLK-CYC activity and the adjustable threshold imposed by CWO keeps E-box-mediated transcription within the controllable range of its activity, thereby rendering a Drosophila circadian clock capable of generating high-amplitude oscillation.