H
Hiroki R. Ueda
Researcher at University of Tokyo
Publications - 247
Citations - 21711
Hiroki R. Ueda is an academic researcher from University of Tokyo. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 59, co-authored 211 publications receiving 18300 citations. Previous affiliations of Hiroki R. Ueda include Intec, Inc. & Osaka University.
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Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins
TL;DR: It is shown that the serine residues upstream of the core LIR of the endoplasmic reticulum (ER)‐phagy receptor TEX264 are phosphorylated by casein kinase 2, which is critical for its interaction with ATG8s, autophagosomal localization, and ER‐ phagy.
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Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors
TL;DR: It is found that picrotoxin acts independently of known Cys-loop receptors to shorten the period of the circadian clock markedly by specifically advancing the accumulation of PERIOD2 protein.
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Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury
Sho Hasegawa,Tsuyoshi Inoue,Tsuyoshi Inoue,Yasuna Nakamura,Yasuna Nakamura,Daichi Fukaya,Daichi Fukaya,Rie Uni,Chia-Hsien Wu,Chia-Hsien Wu,Rie Fujii,Wachirasek Peerapanyasut,Wachirasek Peerapanyasut,Akashi Taguchi,Takahide Kohro,Shintaro Yamada,Mikako Katagiri,Toshiyuki Ko,Seitaro Nomura,Atsuko Ozeki,Etsuo A. Susaki,Hiroki R. Ueda,Nobuyoshi Akimitsu,Youichiro Wada,Issei Komuro,Masaomi Nangaku,Reiko Inagi +26 more
TL;DR: In this paper, the authors performed RNA sequencing of mouse macrophage cell lines to identify the critical gene that mediates the anti-inflammatory effect of β2-adrenergic receptor (Adrb2) signaling.
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A design principle for posttranslational chaotic oscillators.
TL;DR: This work modeled reversible phosphorylation dynamics to elucidate a design principle for autonomous chaos generation that may arise from generic enzymatic reactions, suggesting that chaos behavior may underlie cellular autonomy in a variety of biochemical systems.
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Ca2+-dependent hyperpolarization hypothesis for mammalian sleep.
TL;DR: A recent Ca2+-dependent hyperpolarization hypothesis is introduced, in which the Ca2-dependentHyperpolarized of cortical-membrane potential induces slow-wave oscillation, which may be a fundamental mechanism connecting fast neural activity to the slow dynamics of sleep pressure.